Issues
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Cover image
Cover Image
Cover: The metabolism of cancer cells affects the biology and behaviour of immune cells in the tumour microenvironment. See At A Glance article by Singer et al. (dmm034272). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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SPECIAL ISSUE: Cancer metabolism: models, mechanisms and targets
EDITORIAL
The big picture: exploring the metabolic cross-talk in cancer
Summary: The guest editors of this Special Collection discuss recent advances in the field of cancer metabolism, as well as the challenges faced as this exciting research progresses.
A MODEL FOR LIFE
AT A GLANCE
Immunometabolism in cancer at a glance
Summary: This ‘At a Glance’ review and accompanying poster address how tumors can negatively affect immune cells through depletion of critical nutrients or through production of toxic metabolic products.
REVIEWS
Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
Summary: Here, we discuss the model systems for cancer metabolism studies and highlight their key strengths and pitfalls in addressing different questions, such as how the microenvironment affects cancer metabolism and response to therapy.
Arginine and the metabolic regulation of nitric oxide synthesis in cancer
Summary: In this Review, the authors focus on the regulation of NO levels by the synthesis and availability of arginine, and on the implications of this metabolic regulation to cancer biology and therapy.
The metabolic axis of macrophage and immune cell polarization
Summary: Extracellular metabolites can mediate cell communication and change transcriptional and functional aspects of tumor and normal cells. This Review focuses on how these metabolic cues affect the immune system with a special focus on tumor-associated macrophages.
Hidden features: exploring the non-canonical functions of metabolic enzymes
Summary: This Review summarizes recent findings about multifaceted metabolic enzymes with non-canonical activities outside their core biochemical functions, and how they may provide new therapeutic strategies for cancers.
Metabolic traits of cancer stem cells
Summary: The intrinsic mechanisms that define cancer stem cells, specifically their metabolic properties, are summarized in this Review, in an attempt to point out the benefit of targeting metabolism as a novel therapeutic approach.
The contributions of cancer cell metabolism to metastasis
Summary: In this Review the authors summarize recent findings on how specific metabolic cues modulate and influence the behaviour, genome and epigenome of metastatic cancer cells. They also discuss how the crosstalk between metabolism and the epigenome of metastatic cells can be harnessed to develop new anti-metastatic therapies.
RESEARCH ARTICLES
Synergistic antiproliferative effects of an mTOR inhibitor (rad001) plus gemcitabine on cholangiocarcinoma by decreasing choline kinase activity
Summary: Rad001 plus gemcitabine exerts a synergistic antitumor effect on cholangiocarcinoma irrespective of KRAS mutation status, with underlying mechanisms involving activation of the death receptor, mitochondrial pathways and downregulated choline kinase activity.
A novel zebrafish intestinal tumor model reveals a role for cyp7a1-dependent tumor–liver crosstalk in causing adverse effects on the host
Summary: The authors genetically dissect the adverse effects on the host in a new model of zebrafish intestinal tumor.
Special Issue: The RAS Pathway

Our latest special issue is now complete. It showcases RAS-driven mechanisms of disease progression, and highlights approaches to treat and modify the disease course in model systems.
Call for papers: Moving Heart Failure to Heart Success

Disease Models & Mechanisms is pleased to welcome submissions for consideration for an upcoming special issue, Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy. The deadline for submitting articles to the special issue has been extended to 1 August 2022.
Propose a new Workshop

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A focus on Drosophila

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Apply for a DMM Conference Travel Grant

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