Issues
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Cover image
Cover Image
Cover: An artistic rendition illustrating the progressive nature of the myopathic changes observed upon SIL1 disruption in a mouse model, radiating outward from the endoplasmic reticulum and eventually impinging upon widespread cellular proteostasis. SIL1 is a cofactor for the resident endoplasmic reticulum Hsp70 chaperone, BiP, which plays a key role in maintaining proteostasis in this organelle. Mutations in SIL1 cause Marinesco-Sjögren syndrome, a multisystem, autosomal recessive disorder. Progressive myopathy is a cardinal feature of this disease. Concept: Viraj P. Ichhaporia, Joshua Stokes and Linda M. Hendershot. Electron microscopy image courtesy of: Sharon Frase and Linda Horner. See article by Ichhaporia et al. (dmm033043). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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EDITORIAL
United states of amnesia: rescuing memory loss from diverse conditions
Summary: We examine cases of memory loss caused by diverse interventions, diseases and injuries, and summarize how engram investigation and manipulation may help us understand and potentially treat amnesia.
AT A GLANCE
Molecular biomarkers of Alzheimer's disease: progress and prospects
Summary: This ‘At a glance’ article summarises the molecular biomarkers of Alzheimer's and related diseases, highlighting the challenges and opportunities for diagnostic and prognostic applications.
REVIEW
A guide to using functional magnetic resonance imaging to study Alzheimer's disease in animal models
Summary: This Review examines the use of functional magnetic resonance imaging for studying Alzheimer's disease in animal models, and addresses important considerations concerning model choice, anesthetic use and application of stimuli.
RESEARCH ARTICLES
Functional and genomic characterisation of a xenograft model system for the study of metastasis in triple-negative breast cancer
Summary: Four MDA-MB-231 cell line variants were evaluated for spontaneous metastatic capacity. DNA SNP arrays and RNA-Seq analysis of xenografted tumour cells were conducted to identify genes associated with metastatic proclivity.
Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency
Summary: In a novel ENU mutagenesis mouse model of TPI deficiency, bone marrow transplantation was conducted to demonstrate that haemolytic and red blood cell glycolytic defects can be effectively rescued.
Bruno-3 regulates sarcomere component expression and contributes to muscle phenotypes of myotonic dystrophy type 1
Summary: Our data suggest that, the so far ignored, cytoplasmic Bru-3/CELF1 contributes to myotonic dystrophy type 1 pathogenesis in a Drosophila model by regulating sarcomeric transcripts and protein levels.
Hamartoma-like lesions in the mouse retina: an animal model of Pten hamartoma tumour syndrome
Summary: The authors present the first PHTS animal model that successfully recapitulates hamartoma formation in the retina and can be used to assess drug therapies.
Tumor xenograft modeling identifies an association between TCF4 loss and breast cancer chemoresistance
Summary: By modeling chemoresistance in patient-derived breast cancer xenografts, this study shows that adaptation to therapy is genetically complex and that loss of transcription factor 4 (TCF4) is associated with this process.
SIL1, the endoplasmic-reticulum-localized BiP co-chaperone, plays a crucial role in maintaining skeletal muscle proteostasis and physiology
Editor's choice: This study provides molecular insights into the progressive myopathy and cellular compensatory responses attempted upon loss of SIL1, a component of the endoplasmic-reticulum-resident Hsp70 protein-folding machinery.
Drosophila Insulin receptor regulates the persistence of injury-induced nociceptive sensitization
Summary: Drosophila insulin signaling is required within nociceptive sensory neurons to regulate the persistence of thermal pain sensitization. We describe a model that could be useful to dissect diabetes-induced pain syndromes.
CORRECTION
Call for Papers – Infectious Disease: Evolution, Mechanisms and Global Health

Showcase your latest research on our upcoming Special Issue: Infectious Disease: Evolution, Mechanisms and Global Health. This issue will be coordinated by DMM Editors Sumana Sanyal and David Tobin alongside Guest Editors Judi Allen and Russell Vance. The deadline for submitting articles to this Special Issue has been extended to Monday 24 February 2025.
About us

Our publisher, The Company of Biologists, turns 100 this year. Read about the history of the Company and find out what Sarah Bray, our Chair of the Board of Directors, has to say.
Biologists @ 100 - join us in Liverpool in March 2025

We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate a DMM programme on antimicrobial resistance on 26 March 2025. Find out more and register to join us in March 2025 in Liverpool, UK. The final deadline to register is 28 February 2025.
It's about time: the heterochronic background for the 2024 Nobel Prize in Physiology or Medicine

In this Editorial, Bruce Wightman writes about the groundwork laid by investigating the timing of developmental events in nematodes which led to the 2024 Nobel Prize in Physiology or Medicine.
Read & Publish Open Access publishing: what authors say

We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.