Issues

Summary: We examine cases of memory loss caused by diverse interventions, diseases and injuries, and summarize how engram investigation and manipulation may help us understand and potentially treat amnesia.

Summary: This ‘At a glance’ article summarises the molecular biomarkers of Alzheimer's and related diseases, highlighting the challenges and opportunities for diagnostic and prognostic applications.

Summary: This Review examines the use of functional magnetic resonance imaging for studying Alzheimer's disease in animal models, and addresses important considerations concerning model choice, anesthetic use and application of stimuli.

Summary: Four MDA-MB-231 cell line variants were evaluated for spontaneous metastatic capacity. DNA SNP arrays and RNA-Seq analysis of xenografted tumour cells were conducted to identify genes associated with metastatic proclivity.

Summary: In a novel ENU mutagenesis mouse model of TPI deficiency, bone marrow transplantation was conducted to demonstrate that haemolytic and red blood cell glycolytic defects can be effectively rescued.

Summary: Our data suggest that, the so far ignored, cytoplasmic Bru-3/CELF1 contributes to myotonic dystrophy type 1 pathogenesis in a Drosophila model by regulating sarcomeric transcripts and protein levels.

Summary: The authors present the first PHTS animal model that successfully recapitulates hamartoma formation in the retina and can be used to assess drug therapies.

Summary: By modeling chemoresistance in patient-derived breast cancer xenografts, this study shows that adaptation to therapy is genetically complex and that loss of transcription factor 4 (TCF4) is associated with this process.

Editor's choice: This study provides molecular insights into the progressive myopathy and cellular compensatory responses attempted upon loss of SIL1, a component of the endoplasmic-reticulum-resident Hsp70 protein-folding machinery.

Summary: Drosophila insulin signaling is required within nociceptive sensory neurons to regulate the persistence of thermal pain sensitization. We describe a model that could be useful to dissect diabetes-induced pain syndromes.