Issues
-
Cover image
Cover Image
Cover: Zebrafish chd7 del2 homozygous mutant (bottom) and wild-type fish (top) at 78 hours post-fertilization. Mutant fish have small eyes, an enlarged heart with edema and fail to inflate the swimbladder. The chd7 mutant has a disrupted mRNA reading frame and is a disease model for CHARGE syndrome. See article by Prykhozhij et al. on page 811. Cover image by Sergey Prykhozhij is licensed under a Creative Commons Attribution 4.0 International licence.
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
AT A GLANCE
Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
Summary: This at a glance article gives an overview of the recent knowledge mainly derived from rodent models regarding the CNS-dependent regulation of energy and glucose homeostasis, and depicts how dysregulation of the involved neuronal networks promotes overnutrition and obesity.
REVIEW
Induced pluripotent stem cell models of lysosomal storage disorders
Summary: This Review discusses how induced pluripotent stem cells (iPSCs) provide new opportunities to explore the biology and pathophysiology of lysosomal storage diseases, and how iPSCs have illuminated the role of lysosomes in more common disorders.
RESEARCH ARTICLES
SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression
Editors' choice: A Drosophila model to study the role of PRODH, a schizophrenia-associated gene, in behavioral disorders.
Dietary reversal of neuropathy in a murine model of prediabetes and metabolic syndrome
Summary: A mouse model of metabolic syndrome can be used to investigate peripheral nerve damage, enabling the development of mechanism-based therapies for neuropathy.
Paneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of TLR4 signaling
Summary: Paneth cell disruption and bacterial exposure in immature murine intestine induces NEC-like pathology. Importantly, this occurs independently of TLR4 activation, presenting an alternative mechanism for disease development.
Characterization of Drosophila Saposin-related mutants as a model for lysosomal sphingolipid storage diseases
Summary: Detailed analysis of lipid accumulation, lysosomal dysfunction and neurodegeneration in a Drosophila sphingolipidosis model, suitable for studying the resulting pathological signaling events.
Upregulation of distinct collagen transcripts in post-surgery scar tissue: a study of conjunctival fibrosis
Summary: As well as providing an objective quantitative measure, distinct collagen genes may further aid in the characterization and definition of the development of fibrosis.
A Drosophila model of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects
Summary: Reduced muscle power output and progressive myofibrillar defects in a Drosophila model of inclusion body myopathy 3 arise from the decreased rate of weak to strong actin-binding transition of myosin.
A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress
Summary: A mouse model for renal fibrosis caused by uromodulin mutations reveals roles for ER stress and the unfolded protein response.
Progesterone induces neuroprotection following reperfusion-promoted mitochondrial dysfunction after focal cerebral ischemia in rats
Summary: Progesterone treatment is beneficial in preserving the altered mitochondrial functions in cerebral ischemic injury and thus can help in defining better therapies.
RESOURCE ARTICLES
A classification system for zebrafish adipose tissues
Summary: A standardized nomenclature and classification system for zebrafish adipose tissues and regression models to predict expected adipose size during the course of zebrafish development.
A rapid and effective method for screening, sequencing and reporter verification of engineered frameshift mutations in zebrafish
Summary: A new CRISPR/Cas9-based method of fluorescent reporter technology in zebrafish to confirm loss of gene function in this model.
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy

Registration is now open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease.
Moving towards heart success – Disease Models & Mechanisms Special Issue

DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.
Crossroads in Virology

Our October Editorial written by Sumana Sanyal emphasises the urgency of a concerted effort in understanding virus–host interactions to inform the development of therapeutics and vaccines, helping to predict disease outcomes. Read the full Editorial here.
A Model for Life - an interview with Professor Kiran Musunuru




Read our new A Model for Life interview with Kiran Musunuru. Prof Musunuru investigates the mechanisms of disease in model systems, with the ultimate goal of developing innovative gene editing therapies.
Sustainable Conferencing Initiative

Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share experience about how new technologies and conference formats work in practice.