Issues

Summary: This Review provides an overview of some important microRNAs and their roles in colorectal cancer.

Summary: Subtle alterations in spliceosome structure and function in diabetic sensory neurons, including dysregulated Cajal bodies and CWC22 overexpression, might promote the development of diabetic sensory polyneuropathy.

Summary: A new mouse model reproduces the predominant genetic disposition of patients affected by erythropoietic protoporphyria, a rare disease associated with extreme pain after light exposure.

Summary: Vertical sleeve gastrectomy in mice decreases blood pressure independent of body mass, which may be due to a decrease in hypothalamic ER stress.

Summary: Conditional deletion of Tsc1 in the developing eye results in ciliary body and iris hypotrophy, demonstrating that aberrant mTORC1 signalling contributes to anterior segment dysgenesis (ASD).

Summary: A novel mouse model of autoimmune-mediated heart damage to study the underlying mechanisms and test therapeutic options for systemic autoimmunity.

Editors' choice: Drosophila larvae represent a useful model of infectious inflammation and sterilely induced humoral innate response, which are relevant for disorders associated with chronic inflammation.

Summary: Caveolin 1, which forms caveolae, localizes to the basolateral membrane of zebrafish intestinal epithelial cells and regulates circulating murine fatty acid and lipoprotein cholesterol levels.

Summary: Comparative genome analyses identify candidate genes for hypertension and insulin resistance on rat chromosomes 12 and 16, and marked enrichment of insulin resistance genes in the syntenic regions of the human genome.

Summary: New transgenic models for exocrine pancreas regeneration in zebrafish reveal a novel potential exocrine progenitor as the source for a two-phase regeneration process after complete acinar cell loss.

Summary: Hippocampal functional activity and neuroplasticity are altered in mice long withdrawn from cocaine, with concomitant memory deficits, emphasizing the role of the hippocampus in persistent cognitive manifestation of cocaine withdrawal.

Summary: A phenotype-based chemical screen in zebrafish identifies miconazole as a novel hemorrhagic suppressor. Miconazole inhibits vessel rupture and hemorrhages by decreasing pErk and MMP9 in zebrafish and rats.