Summary: This Review summarizes the similarities between cardiac and vascular valves, and highlights unanswered questions in diagnosis and treatment of valve disorders.
Summary: Chronic middle ear inflammation is a common disease. Animal models, and in particular mouse models, have been used to elucidate some potential mechanisms, including dysfunction in immune signalling, mucociliary function or Eustachian tube function.
Summary: Transforming growth factor-β-induced collagen remodelling is driven by enhanced lysyl oxidase expression in idiopathic pulmonary fibrosis.
RhoB blockade selectively inhibits autoantibody production in autoimmune models of rheumatoid arthritis and lupus
Editors' choice: The small GTPase RhoB participates in the development of an autoimmune response, specifically by influencing the production of pathogenic autoantibodies.
Summary: Identification of a microRNA that suppresses Rac2 expression and regulates neutrophil migration and systemic inflammation. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.
Summary: Epileptogenic risk factors are misregulated in Pumilio2-deficient mice, determining a predisposition to develop seizures. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.
Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia
Summary: Our findings identify early cerebellar mitochondrial biogenesis deficits as a potential mediator of cerebellar dysfunction and ataxia, and indicate a potential therapeutic target for early intervention of Friedreich ataxia.
Comprehensive analysis of gene expression patterns in Friedreich's ataxia fibroblasts by RNA sequencing reveals altered levels of protein synthesis factors and solute carriers
Summary: Transcriptome profiling of Friedreich's ataxia fibroblasts by RNA sequencing reveals that this peripheral tissue can be used as a disease model for gene expression biomarker discovery.
Summary: A new model of antibiotic-treated severe pyelonephritis offers a novel platform to study the molecular pathogenesis of pyelonephritis, response to antibiotic therapy, and sequelae, including fibrosis and renal scarring.