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Cover image
Cover Image
Cover: Immunofluorescence image showing a section of an intraductal adenoma with stroma within a prostate carcinoma of a 30-week-old TRAMP mouse carrying an Acta2-CreER transgene and R26LSL-tdTomato/+ reporter given tamoxifen at 4 weeks. Red indicates tdTomato+ cells derived from Acta2-expressing cells at 4 weeks, green indicates cells expressing ACTA2+ (smooth muscle cells), blue indicates DAPI staining of nuclei. As described in the article by Yang et al. on page 39, Acta2-expressing cells of the smooth muscle-lineage expand not only in the smooth muscle layers, but also invade into intraductal stromal space between epithelium folds and become cancer reactive stroma. Thus, smooth muscle lineage is a cell-of-origin for intraductal cancer reactive stroma in TRAMP. Image created by Zhaohui Yang and licenced under a Creative Commons Attribution 4.0 International licence.
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Call for Papers – Infectious Disease: Evolution, Mechanisms and Global Health
Showcase your latest research on our upcoming Special Issue: Infectious Disease: Evolution, Mechanisms and Global Health. This issue will be coordinated by DMM Editors Sumana Sanyal and David Tobin alongside Guest Editors Judi Allen and Russell Vance. The deadline for submitting articles to this Special Issue has been extended to Monday 24 February 2025.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate a DMM programme on antimicrobial resistance on 26 March 2025. Find out more and register to join us in March 2025 in Liverpool, UK. The final deadline to register is 28 February 2025.
It's about time: the heterochronic background for the 2024 Nobel Prize in Physiology or Medicine
In this Editorial, Bruce Wightman writes about the groundwork laid by investigating the timing of developmental events in nematodes which led to the 2024 Nobel Prize in Physiology or Medicine.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
