Issues
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Cover image
Cover Image
Double in situ hybridisation on a presomitic-stage mouse embryo showing the expression domains of Hesx1 (red) and Pax2 (purple). See research article by Sajedi et al. on page 241. - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
EDITORIAL
COMMUNITY NEWS
A MODEL FOR LIFE
The first transgenic mice: an interview with Mario Capecchi
Mario Capecchi recently won the Nobel Prize for contributions to genetics that have catapulted the mouse to the status of the most valuable of all animal models. He has a personal story that is as rich and interesting as his science. Here, he discusses the journey that led him to gene targeting and his vision for the future.
FEATURE
Promoting translational research at Vanderbilt University’s CTSA institute
As part of a national consortium to efficiently advance patient care, Vanderbilt University is approaching translational medicine in creative new ways. Kristin Kain investigates.
PRIMER
SPECIAL ARTICLE
COMMENTARY
PERSPECTIVE
RESEARCH ARTICLE
Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism
RESEARCH REPORT
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy
Registration is now open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease.
Moving towards heart success – Disease Models & Mechanisms Special Issue
DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.
Crossroads in Virology
Our October Editorial written by Sumana Sanyal emphasises the urgency of a concerted effort in understanding virus–host interactions to inform the development of therapeutics and vaccines, helping to predict disease outcomes. Read the full Editorial here.
A Model for Life - an interview with Professor Kiran Musunuru
Read our new A Model for Life interview with Kiran Musunuru. Prof Musunuru investigates the mechanisms of disease in model systems, with the ultimate goal of developing innovative gene editing therapies.
Sustainable Conferencing Initiative
Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share experience about how new technologies and conference formats work in practice.
