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Moving Heart Failure to Heart Success

Despite significant progress, cardiac disease that results in heart failure remains a significant clinical and scientific challenge. This collection, launching with our upcoming special issue Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy , guest edited by Jeroen Bakkers, Milena Bellin and Ravi Karra, includes research and review-type articles on the dysregulation of pathways, disease progression, and approaches to treat and modify the course of heart failure.

Other subject collections

REVIEW

Nuclear mechanosensing of the aortic endothelium in health and disease

Aarren J. Mannion; Lars Holmgren

01 November 2023

10.1242/dmm.050361

RESEARCH ARTICLE

Comparative multi-omic analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency

Nicole M. Sayles; Jill S. Napierala; Josef Anrather; Nadège Diedhiou; Jixue Li; Marek Napierala; Hélène Puccio; Giovanni Manfredi

09 October 2023

10.1242/dmm.050114

RESEARCH ARTICLE

Modeling a variant of unknown significance in the Drosophila ortholog of the human cardiogenic gene NKX2.5

TyAnna L. Lovato; Brenna Blotz; Cayleen Bileckyj; Christopher A. Johnston; Richard M. Cripps

29 September 2023

10.1242/dmm.050059

RESEARCH ARTICLE

CRISPR-based knockout and base editing confirm the role of MYRF in heart development and congenital heart disease

Lino Doering; Alex Cornean; Thomas Thumberger; Joergen Benjaminsen; Beate Wittbrodt; Tanja Kellner; Omar T. Hammouda; Matthias Gorenflo; Joachim Wittbrodt; Jakob Gierten

16 August 2023

10.1242/dmm.049811

RESEARCH ARTICLE

Multiplatform modeling of atrial fibrillation identifies phospholamban as a central regulator of cardiac rhythm

Anaïs Kervadec; James Kezos; Haibo Ni; Michael Yu; James Marchant; Sean Spiering; Suraj Kannan; Chulan Kwon; Peter Andersen; Rolf Bodmer; Eleonora Grandi; Karen Ocorr; Alexandre R. Colas

17 July 2023

10.1242/dmm.049962

RESEARCH ARTICLE

Immature human engineered heart tissues engraft in a guinea pig chronic injury model

Constantin von Bibra; Aya Shibamiya; Andrea Bähr; Birgit Geertz; Maria Köhne; Tim Stuedemann; Jutta Starbatty; Verena Horneffer-van der Sluis; Ulrich C. Klostermeier; Nadja Hornaschewitz; Xinghai Li; Eckhard Wolf; Nikolai Klymiuk; Markus Krane; Christian Kupatt; Bernhard Hiebl; Thomas Eschenhagen; Florian Weinberger

05 June 2023

10.1242/dmm.049834

EDITORIAL

From mechanisms of heart failure to clinical heart success

Jeroen Bakkers; Milena Bellin; Julija Hmeljak; Ravi Karra

05 June 2023

10.1242/dmm.050282

RESEARCH ARTICLE

Deficiency in hereditary hemorrhagic telangiectasia-associated Endoglin elicits hypoxia-driven heart failure in zebrafish

Etienne Lelièvre; Charlotte Bureau; Yann Bordat; Maxence Frétaud; Christelle Langevin; Chris Jopling; Karima Kissa

02 June 2023

10.1242/dmm.049488

PERSPECTIVE

Designer pigs for xenogeneic heart transplantation and beyond

Eckhard Wolf; Bruno Reichart; Alessandra Moretti; Karl-Ludwig Laugwitz

30 May 2023

10.1242/dmm.050177

REVIEW

Gene editing innovations and their applications in cardiomyopathy research

Eirini Kyriakopoulou; Thomas Monnikhof; Eva van Rooij

24 May 2023

10.1242/dmm.050088

A MODEL FOR LIFE

Getting to the heart of stem cell research: an interview with Christine Mummery

Christine Mummery

23 May 2023

10.1242/dmm.050270

REVIEW

Genetics of sinoatrial node function and heart rate disorders

Lieve E. van der Maarel; Alex V. Postma; Vincent M. Christoffels

17 May 2023

10.1242/dmm.050101

RESEARCH ARTICLE

A gut microbiome metabolite paradoxically depresses contractile function while activating mitochondrial respiration

Saba Naghipour; Joshua J. Fisher; Anthony V. Perkins; Jason N. Peart; John P. Headrick; Eugene F. Du Toit

15 May 2023

10.1242/dmm.049975

REVIEW

Lateral thinking in syndromic congenital cardiovascular disease

Agnese Kocere; Robert L. Lalonde; Christian Mosimann; Alexa Burger

02 May 2023

10.1242/dmm.049735

A MODEL FOR LIFE

Lifting the cloche : Jeroen Bakkers interviews Didier Stainier

Didier Y. R. Stainier; Jeroen Bakkers

28 March 2023

10.1242/dmm.050147

RESOURCE ARTICLE

Knockout mice are an important tool for human monogenic heart disease studies

Pilar Cacheiro; Nadine Spielmann; Hamed Haseli Mashhadi; Helmut Fuchs; Valerie Gailus-Durner; Damian Smedley; Martin Hrabĕ de Angelis

21 March 2023

10.1242/dmm.049770

AT A GLANCE

Heart in a dish – choosing the right in vitro model

Lika Drakhlis; Robert Zweigerdt

24 February 2023

10.1242/dmm.049961

RESEARCH ARTICLE

Piglet cardiopulmonary bypass induces intestinal dysbiosis and barrier dysfunction associated with systemic inflammation

Jeffrey D. Salomon; Haowen Qiu; Dan Feng; Jacob Owens; Ludmila Khailova; Suzanne Osorio Lujan; John Iguidbashian; Yashpal S. Chhonker; Daryl J. Murry; Jean-Jack Riethoven; Merry L. Lindsey; Amar B. Singh; Jesse A. Davidson

12 January 2023

10.1242/dmm.049742

RESEARCH ARTICLE

A DUSP6 inhibitor suppresses inflammatory cardiac remodeling and improves heart function after myocardial infarction

Zongwang Zhang; Yang Chen; Lixia Zheng; Jianyong Du; Shicheng Wei; Xiaojun Zhu; Jing-Wei Xiong

07 December 2022

10.1242/dmm.049662

RESEARCH ARTICLE

Maternal heterozygosity of Slc6a19 causes metabolic perturbation and congenital NAD deficiency disorder in mice

Hartmut Cuny; Kayleigh Bozon; Rosemary B. Kirk; Delicia Z. Sheng; Stefan Bröer; Sally L. Dunwoodie

14 November 2022

10.1242/dmm.049647

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Pre-clinical Modelling of human Genetic Disease and Therapy ad depicting a fluorescently dyed image of neurons in the background

Registration is now open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease.

Moving towards heart success – Disease Models & Mechanisms Special Issue

Special issue advert depicting images of hearts

DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.

Crossroads in Virology

Zoonotic spillover and virus–host interactions.

Our October Editorial written by Sumana Sanyal emphasises the urgency of a concerted effort in understanding virus–host interactions to inform the development of therapeutics and vaccines, helping to predict disease outcomes. Read the full Editorial here.

A Model for Life - an interview with Professor Kiran Musunuru

Read our new A Model for Life interview with Kiran Musunuru. Prof Musunuru investigates the mechanisms of disease in model systems, with the ultimate goal of developing innovative gene editing therapies.

Sustainable Conferencing Initiative

Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share experience about how new technologies and conference formats work in practice.

Moving Heart Failure to Heart Success

DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy

Moving towards heart success – Disease Models & Mechanisms Special Issue

Crossroads in Virology

A Model for Life - an interview with Professor Kiran Musunuru

Sustainable Conferencing Initiative

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