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Cancer

The complexity of cancer has prompted scientists worldwide to employ animal and cell-based models to investigate the mechanisms underlying the disease. Recent advances in cancer models and the increasing sophistication of high-throughput systems and genomics tools now enable researchers to better model and target this multi-aetiology disease. This collection features research articles and reviews that help accelerate translation into potential therapeutics to stop disease progression and prolong patient lives.

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RESOURCE ARTICLE

Long-term non-invasive drug treatments in adult zebrafish that lead to melanoma drug resistance

Yuting Lu; E. Elizabeth Patton

09 May 2022

Doi: 10.1242/dmm.049401

RESOURCE ARTICLE

Clinically relevant orthotopic xenograft models of patient-derived glioblastoma in zebrafish

Xiaolin Ai; Zengpanpan Ye; Chaoxin Xiao; Jian Zhong; Joseph J. Lancman; Xuelan Chen; Xiangyu Pan; Yu Yang; Lin Zhou; Xiang Wang; Huashan Shi; Dongmei Zhang; Yuqin Yao; Dan Cao; Chengjian Zhao

26 April 2022

Doi: 10.1242/dmm.049109

RESEARCH ARTICLE

Aberrant RET expression affects normal mammary gland post-lactation transition, enhancing cancer potential

Sabrina A. Vallone; Martín García Solá; Carolina Schere-Levy; Roberto P. Meiss; Gladys N. Hermida; Lewis A. Chodosh; Edith C. Kordon; Nancy E. Hynes; Albana Gattelli

29 March 2022

Doi: 10.1242/dmm.049286

RESEARCH ARTICLE

Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis

Ajai J. Pulianmackal; Kiriaki Kanakousaki; Kerry Flegel; Olga G. Grushko; Ella Gourley; Emily Rozich; Laura A. Buttitta

16 March 2022

Doi: 10.1242/dmm.049234

REVIEW

RAS-mediated tumor stress adaptation and the targeting opportunities it presents

Alexandra Redding; Andrew E. Aplin; Elda Grabocka

11 February 2022

Doi: 10.1242/dmm.049280

RESEARCH ARTICLE

Two cell line models to study multiorganic metastasis and immunotherapy in lung squamous cell carcinoma

Karmele Valencia; Cristina Sainz; Cristina Bértolo; Gabriel de Biurrun; Jackeline Agorreta; Arantza Azpilikueta; Marta Larrayoz; Graziella Bosco; Carolina Zandueta; Miriam Redrado; Esther Redín; Francisco Exposito; Diego Serrano; Mirari Echepare; Daniel Ajona; Ignacio Melero; Ruben Pio; Roman Thomas; Alfonso Calvo; Luis M. Montuenga

31 January 2022

Doi: 10.1242/dmm.049137

RESEARCH ARTICLE

Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling

Roger S. Smith; Igor Odintsov; Zebing Liu; Allan Jo-Weng Lui; Takuo Hayashi; Morana Vojnic; Yoshiyuki Suehara; Lukas Delasos; Marissa S. Mattar; Julija Hmeljak; Hillary A. Ramirez; Melissa Shaw; Gabrielle Bui; Alifiani B. Hartono; Eric Gladstone; Siddharth Kunte; Heather Magnan; Inna Khodos; Elisa De Stanchina; Michael P. La Quaglia; Jinjuan Yao; Marick Laé; Sean B. Lee; Lee Spraggon; Christine A. Pratilas; Marc Ladanyi; Romel Somwar

27 January 2022

Doi: 10.1242/dmm.047621

REVIEW

Alternative RNA splicing in tumour heterogeneity, plasticity and therapy

Sebastian Öther-Gee Pohl; Kevin B. Myant

11 January 2022

Doi: 10.1242/dmm.049233

RESEARCH ARTICLE

Statins mediate anti- and pro-tumourigenic functions by remodelling the tumour microenvironment

Tamihiro Kamata; Esraa Al Dujaily; Salwa Alhamad; Tsz Y. So; Olga Margaritaki; Susan Giblett; J. Howard Pringle; John Le Quesne; Catrin Pritchard

04 January 2022

Doi: 10.1242/dmm.049148

RESEARCH ARTICLE

TP53 loss initiates chromosomal instability in fallopian tube epithelial cells

Daniel Bronder; Anthony Tighe; Darawalee Wangsa; Dali Zong; Thomas J. Meyer; René Wardenaar; Paul Minshall; Daniela Hirsch; Kerstin Heselmeyer-Haddad; Louisa Nelson; Diana Spierings; Joanne C. McGrail; Maggie Cam; André Nussenzweig; Floris Foijer; Thomas Ried; Stephen S. Taylor

30 November 2021

Doi: 10.1242/dmm.049001

RESEARCH ARTICLE

Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma

Camila Robles-Oteiza; Deborah Ayeni; Stellar Levy; Robert J. Homer; Susan M. Kaech; Katerina Politi

15 November 2021

Doi: 10.1242/dmm.049072

REVIEW

Infant leukaemia – faithful models, cell of origin and the niche

Alasdair Duguid; Domenico Mattiucci; Katrin Ottersbach

29 October 2021

Doi: 10.1242/dmm.049189

REVIEW

Engineering chromosome rearrangements in cancer

Salvador Alonso; Lukas E. Dow

29 September 2021

Doi: 10.1242/dmm.049078

RESEARCH ARTICLE

Comparison of the oncogenomic landscape of canine and feline hemangiosarcoma shows novel parallels with human angiosarcoma

Kim Wong; Latasha Ludwig; Oscar Krijgsman; David J. Adams; Geoffrey A. Wood; Louise van der Weyden

23 July 2021

Doi: 10.1242/dmm.049044

RESOURCE ARTICLE

Extramedullary multiple myeloma patient-derived orthotopic xenograft with a highly altered genome: combined molecular and therapeutic studies

Lourdes Farre; Gabriela Sanz; Neus Ruiz-Xivillé; Manuel Castro de Moura; Juan Francisco Martin-Tejera; Samuel Gonçalves-Ribeiro; Maria Martinez-Iniesta; Monica Calaf; Jose Luis Mosquera; José Ignacio Martín-Subero; Isabel Granada; Manel Esteller; Eva Domingo-Domenech; Fina Climent; Alberto Villanueva; Anna Sureda

15 July 2021

Doi: 10.1242/dmm.048223

PERSPECTIVE

Western lifestyle as a driver of dysbiosis in colorectal cancer

Nora J. Foegeding; Zachary S. Jones; Mariana X. Byndloss

01 June 2021

Doi: 10.1242/dmm.049051

RESEARCH ARTICLE

Reproductive history determines Erb b 2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model

Liliana D. Ordonez; Lorenzo Melchor; Kirsty R. Greenow; Howard Kendrick; Giusy Tornillo; James Bradford; Peter Giles; Matthew J. Smalley

18 May 2021

Doi: 10.1242/dmm.048736