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Model Systems in Drug Discovery

Model systems are central to the discovery and development of new and better treatments for human disease. DMM is committed to supporting and inspiring scientists to promote collaboration in translational science. This collection, first launched in 2015 with a special issue From Bench to Patient: Model Systems in Drug Discovery, guest edited by Matthew Breyer and Thomas Look, highlights the contribution of model systems to drug discovery and optimisation across multiple disease areas. It features reviews and research articles on the use of model systems to test or develop new therapies.

Other subject collections

Special Collection Image
PERSPECTIVE
James F. Amatruda
Doi: 10.1242/dmm.048930
RESEARCH ARTICLE
Henrika Jodeleit; Paula Winkelmann; Janina Caesar; Sebastian Sterz; Lesca M. Holdt; Florian Beigel; Johannes Stallhofer; Simone Breiteneicher; Eckart Bartnik; Thomas Leeuw; Matthias Siebeck; Roswitha Gropp
Doi: 10.1242/dmm.046995
RESEARCH ARTICLE
Lozan Sheriff; Reenam S. Khan; Raquel Saborano; Richard Wilkin; Nguyet-Thin Luu; Ulrich L. Gunther; Stefan G. Hubscher; Philip N. Newsome; Patricia F. Lalor
Doi: 10.1242/dmm.046383
RESEARCH ARTICLE
Katie Lloyd; Stamatia Papoutsopoulou; Emily Smith; Philip Stegmaier; Francois Bergey; Lorna Morris; Madeleine Kittner; Hazel England; Dave Spiller; Mike H. R. White; Carrie A. Duckworth; Barry J. Campbell; Vladimir Poroikov; Vitor A. P. Martins dos Santos; Alexander Kel; Werner Muller; D. Mark Pritchard; Chris Probert; Michael D. Burkitt; The SysmedIBD Consortium
Doi: 10.1242/dmm.044040
RESEARCH ARTICLE
Pingtao Tang; Jharna R. Das; Jinliang Li; Jing Yu; Patricio E. Ray
Doi: 10.1242/dmm.045641
REVIEW
Alec M. DeSimone; Justin Cohen; Monkol Lek; Angela Lek
Doi: 10.1242/dmm.046904
AT A GLANCE
Kim A. Caldwell; Corey W. Willicott; Guy A. Caldwell
Doi: 10.1242/dmm.046110
RESEARCH ARTICLE
Angelino T. Tromp; Yuxi Zhao; Ilse Jongerius; Erik C. J. M. Heezius; Pauline Abrial; Maartje Ruyken; Jos A. G. van Strijp; Carla J. C. de Haas; András N. Spaan; Kok P. M. van Kessel; Thomas Henry; Pieter-Jan A. Haas
Doi: 10.1242/dmm.045534
REVIEW
Anni K. Saralahti; Meri I. E. Uusi-Mäkelä; Mirja T. Niskanen; Mika Rämet
Doi: 10.1242/dmm.045716
REVIEW
Jeffrey W. Santoso; Megan L. McCain
Doi: 10.1242/dmm.044867
REVIEW
Mark L. Kovler; Chhinder P. Sodhi; David J. Hackam
Doi: 10.1242/dmm.044388
REVIEW
Maaike van Putten; Erin M. Lloyd; Jessica C. de Greef; Vered Raz; Raffaella Willmann; Miranda D. Grounds
Doi: 10.1242/dmm.043562
REVIEW
Raffaella Willmann; Joanne Lee; Cathy Turner; Kanneboyina Nagaraju; Annemieke Aartsma-Rus; Dominic J. Wells; Kathryn R. Wagner; Cristina Csimma; Volker Straub; Miranda D. Grounds; Annamaria De Luca
Doi: 10.1242/dmm.042903
RESEARCH ARTICLE
Sangeetha Iyer; Feba S. Sam; Nina DiPrimio; Graeme Preston; Jan Verheijen; Kausalya Murthy; Zachary Parton; Hillary Tsang; Jessica Lao; Eva Morava; Ethan O. Perlstein
Doi: 10.1242/dmm.040584
RESEARCH ARTICLE
Sangeetha Iyer; Joshua D. Mast; Hillary Tsang; Tamy P. Rodriguez; Nina DiPrimio; Madeleine Prangley; Feba S. Sam; Zachary Parton; Ethan O. Perlstein
Doi: 10.1242/dmm.040576
SPECIAL ARTICLE
Robert Brommage; David R. Powell; Peter Vogel
Doi: 10.1242/dmm.038224
RESEARCH ARTICLE
Thomas Delerue; Déborah Tribouillard-Tanvier; Marlène Daloyau; Farnoosh Khosrobakhsh; Laurent Jean Emorine; Gaëlle Friocourt; Pascale Belenguer; Marc Blondel; Laetitia Arnauné-Pelloquin
Doi: 10.1242/dmm.036558
RESEARCH ARTICLE
Piotr Soczewka; Damian Kolakowski; Iwona Smaczynska-de Rooij; Weronika Rzepnikowska; Kathryn R. Ayscough; Joanna Kaminska; Teresa Zoladek
Doi: 10.1242/dmm.036830
RESOURCE ARTICLE
Maria R. Replogle; Virinchipuram S. Sreevidya; Vivian M. Lee; Michael D. Laiosa; Kurt R. Svoboda; Ava J. Udvadia
Doi: 10.1242/dmm.035097
RESEARCH ARTICLE
Jennifer E. Hewitt; Amelia K. Pollard; Leila Lesanpezeshki; Colleen S. Deane; Christopher J. Gaffney; Timothy Etheridge; Nathaniel J. Szewczyk; Siva A. Vanapalli
Doi: 10.1242/dmm.036137
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