Epilepsy affects millions of people worldwide, but many patients do not respond well to treatment or develop drug-resistant seizures. Many animal models of seizure exist, but additional, more economical systems are required for high-throughput drug testing and basic research. Lee et al. report a new model involving exposure of zebrafish larvae to ginkgotoxin, which induces seizure-like swimming behaviour that is reversed by commonly used anti-epileptic drugs. In addition, the phenotype is reversed by the inhibitory neurotransmitter GABA or PLP, an upstream enzyme in the GABA synthesis pathway. This model provides a system for addressing a proposed mechanism of seizure involving GABA, and introduces a relatively simple new platform for high-throughput drug screening. Page 785
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IN THIS ISSUE| 01 November 2012
New zebrafish model of seizure
Online ISSN: 1754-8411
Print ISSN: 1754-8403
Written by editorial staff. © 2012. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
Dis Model Mech (2012) 5 (6): 707.
New zebrafish model of seizure. Dis Model Mech 1 November 2012; 5 (6): 707. doi:
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