The increasing incidence of obesity brings a parallel increase in type 2 diabetes (T2D), a metabolic complication of excess body weight. Despite recent improvements in pharmacotherapy, T2D symptoms are not normalised in up to 50% of patients, meaning a continued high risk of additional serious complications. Bariatric surgery, which involves the removal or re-routing of parts of the stomach and/or intestine, is known to provide significant weight-loss in the morbidly obese. However, whether these procedures can improve uncontrolled T2D, particularly in moderately obese individuals, has been unclear. Now, Schauer et al. report the first controlled trial comparing the results of bariatric surgery with medication versus medication alone in obese subjects with uncontrolled T2D. After 12 months, patients that underwent bariatric surgery had lost more weight and had decreased their medication use, whereas those receiving medication alone had lost very little weight and had increased their medication use. Although glycaemic control improved in all groups, 42% of those in the surgery cohort had normalised blood glucose, compared with only 12% in the medication alone group. Although larger studies will be needed to assess long-term outcomes, this study suggests that bariatric surgery combined with medication is a promising therapy for obese individuals with T2D.
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RESEARCH HIGHLIGHT| 01 September 2012
Bariatric surgery for T2D in obesity
Online Issn: 1754-8411
Print Issn: 1754-8403
Written by editorial staff. © 2012. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
Dis Model Mech (2012) 5 (5): 567.
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Bariatric surgery for T2D in obesity. Dis Model Mech 1 September 2012; 5 (5): 567. doi:
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