Obese individuals are at high risk of developing kidney disease, which can lead to renal failure requiring dialysis or transplant. Few models of obesity-associated kidney disease exist, so investigating the association has been a challenge. Martínez-García et al. now report a model that enables the study of kidney disease in the context of obesity. They crossed ob/ob mice (which store large amounts of fat) with mice lacking PPARγ (which are impaired in generating fat tissue) to generate ‘POKO mice’, which have high circulating levels of glucose and fat. At just 4 weeks old, POKO mice show kidney dysfunction associated with inflammation, fibrosis and lipid accumulation – all signs of advanced kidney disease. Kidney pathology advances to severe by 12 weeks. These data introduce the POKO mouse as a new model of obesity-associated kidney disease, and indicate that glucolipotoxicity can accelerate the condition. Page 636
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IN THIS ISSUE| 01 September 2012
‘POKO mice’ enable studies of obesity-associated kidney disease
Online Issn: 1754-8411
Print Issn: 1754-8403
Written by editorial staff. © 2012. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
Dis Model Mech (2012) 5 (5): 566.
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‘POKO mice’ enable studies of obesity-associated kidney disease. Dis Model Mech 1 September 2012; 5 (5): 566. doi:
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