Much effort has been invested in determining how Salmonella virulence factors cause acute gastroenteritis. There has been debate about whether and how the Salmonella enterotoxin Stn contributes to the virulence of the bacteria. Nakano et al. find that a Δstn strain is no less virulent in vitro or in vivo than wild type. However, proteomic profiling shows that Δstn has abnormal membrane localisation of OmpA, a highly immunogenic outer membrane protein that is important for bacterial homeostasis. In addition, Stn and OmpA are found to directly interact. Thus, Stn might be important for bacterial cell membrane integrity through regulating the localisation of OmpA. Page 515
Skip Nav Destination
IN THIS ISSUE| 01 July 2012
Salmonella virulence factor Stn: role in membrane integrity
Online ISSN: 1754-8411
Print ISSN: 1754-8403
Written by editorial staff. © 2012. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms
Dis Model Mech (2012) 5 (4): 413.
Salmonella virulence factor Stn: role in membrane integrity. Dis Model Mech 1 July 2012; 5 (4): 413. doi:
Download citation file: