It is thought that selection determines which cells in a tissue give rise to a tumour through clonal expansion. Identifying biomarkers that detect this early precancerous process might enable prevention before tumours form. Based on findings that Flower protein marks pretumoral cells in Drosophila, Petrova et al. set out to study whether the mouse homologue (mFwe) has the same function. They show that mFwe expression is increased in skin cells surrounding papillomas in mice, and that mFwe-deficient mice develop normally but are resistant to chemically induced skin papillomas, suggesting that mFwe promotes the expansion of pretumoral cells. These data suggest that Flower protein might be a biomarker for early skin cancer detection and a potential drug target. Page 553
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IN THIS ISSUE| 01 July 2012
Flower protein: biomarker for early cancer detection?
Online Issn: 1754-8411
Print Issn: 1754-8403
Written by editorial staff. © 2012. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms
Dis Model Mech (2012) 5 (4): 413.
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Flower protein: biomarker for early cancer detection?. Dis Model Mech 1 July 2012; 5 (4): 413. doi:
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