Dysregulated Myc expression is observed in many types of cancer, in line with the known role of this transcription factor in regulating cellular processes such as apoptosis, proliferation and differentiation. Investigating the function of Myc in diverse biological models provides clues to its role in cancer. Menescal et al. analyse a newly identified, unusual version of Myc (myc17) found in the medaka genome, which also contains a conventional, conserved version of Myc (myc20). Although Myc17 lacks protein-regulatory sequences found in other reported versions of Myc, studies of two inducible transgenic medaka lines show that Myc17 is functional and, like other versions of Myc, drives apoptosis and proliferation in vivo. In addition, long-term myc17 induction causes liver hyperplasia. These transgenic medaka lines can be further used to probe the role of Myc in liver tumorigenesis. Page 492
Newly identified medaka myc17 gene induces liver hyperplasia
Newly identified medaka myc17 gene induces liver hyperplasia. Dis Model Mech 1 July 2012; 5 (4): 413–414. doi:
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DMM Journal Meeting 2023: Infectious Diseases Through an Evolutionary Lens
The abstract submission deadline for our 2023 Journal Meeting ‘Infectious Diseases Through an Evolutionary Lens’ is 14 July 2023. Find out more and register here.
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Do you have an idea for a Workshop? If so, click here. We are now accepting proposals for our 2025 Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South country to host an event overseas.
How stromal cells restrict liver cancer invasion
In our recent editor’s choice, Liqin Zhu and colleagues describe how they used in vitro liver spheroid models consisting of both parenchymal and non-parenchymal cells to reveal a hepatoprotective role for peritumoral hepatic stellate cells in liver tumorigenesis.
And from perspective… Hacking haematopoiesis – emerging tools for examining variant effects
Thousands of genomic loci have been linked to hematopoietic traits and diseases, yet many await functional validation. Michael Gundry and Vijay G. Sankaran discuss recent advances in genome editing and the challenges associated with using these techniques to assess variant function in primary hematopoietic cells.
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