Nemaline myopathy (NM) is a common childhood disorder causing severe disability and premature death. Mouse models have been developed, but many questions about the disease remain unanswered, and there are no therapies. Telfer et al. report the first zebrafish model of NM, which carries a splice-site mutation in nebulin, a homologue of the most common genetic culprit causing NM in humans. The mutant has many features of the human disease and will be important for further basic studies on the pathology of NM, as well as high-throughput screening for candidate therapies. Page 389
Written by editorial staff. © 2012. Published by The Company of Biologists Ltd
2012
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