8q24 is a gene desert associated with increased risk for prostate and other types of cancer. Ting et al. investigated how this region confers risk by studying its function at the molecular level. This group previously showed that 8q24 contains several regions with enhancer activity in vitro. Here, they characterise one enhancer region, called AcP10, containing a risk-associated SNP, in vivo. Transgenic mice expressing AcP10 show activation of a reporter gene in a subset of Nkx3.1-expressing lumenal epithelial cells in the prostate that have stem-like properties and are thought to be crucial for tumorigenesis. Page 366

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