The sophistication of genetic tools and the relative ease of breeding and housing mean that the mouse is currently the most widely used organism for disease research. The genotype-phenotype information that will emerge from the efforts of the International Mouse Phenotyping Consortium (IMPC), now well into its first year, will advance disease research further still. In the Editorial on page , Steve Brown, Chair of the IMPC’s International Steering Committee, and Mark Moore, the IMPC’s Executive Director, outline the objectives of the next 10 years of the project. We also present Perspectives that review three areas in which mouse models are helping to unravel disease mechanisms. Norris and Grimes discuss mouse models of ciliopathies (page ), Jaeger and Nath propose a new mouse model for HIV-associated neurocognitive disorders (page ), and Ahmad et al. explain how genetically modified mice are being used to dissect the complex and heterogeneous signalling pathways that underlie bladder cancer (page ).
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May 2012
DMM Journal Meeting 2023: Infectious Diseases Through an Evolutionary Lens
The abstract submission deadline for our 2023 Journal Meeting ‘Infectious Diseases Through an Evolutionary Lens’ is 14 July 2023. Find out more and register here.
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Do you have an idea for a Workshop? If so, click here. We are now accepting proposals for our 2025 Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South country to host an event overseas.
How stromal cells restrict liver cancer invasion
In our recent editor’s choice, Liqin Zhu and colleagues describe how they used in vitro liver spheroid models consisting of both parenchymal and non-parenchymal cells to reveal a hepatoprotective role for peritumoral hepatic stellate cells in liver tumorigenesis.
And from perspective… Hacking haematopoiesis – emerging tools for examining variant effects
Thousands of genomic loci have been linked to hematopoietic traits and diseases, yet many await functional validation. Michael Gundry and Vijay G. Sankaran discuss recent advances in genome editing and the challenges associated with using these techniques to assess variant function in primary hematopoietic cells.
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