Cerebral ischemia caused by occlusion of blood flow causes damage to brain tissue, leading to severe neurological and psychological symptoms or even death if not resolved quickly. Hori et al. use a whole-genome DNA microarray approach to characterise the molecular events of an ischemic episode in mice. The data confirm previous findings that inflammatory pathways are activated, but also show an up- or downregulation in the expression of many genes not previously associated with cerebral ischemia. This study provides new candidate genes and pathways for cerebral ischemia, as well as clues about endogenous factors that might prevent or reverse tissue damage. Page 270
Skip Nav Destination
IN THIS ISSUE| 01 March 2012
Profiling gene expression during cerebral ischemia
Online ISSN: 1754-8411
Print ISSN: 1754-8403
Written by editorial staff. © 2012. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
Dis Model Mech (2012) 5 (2): 148.
Profiling gene expression during cerebral ischemia. Dis Model Mech 1 March 2012; 5 (2): 148. doi:
Download citation file: