Cerebral ischemia caused by occlusion of blood flow causes damage to brain tissue, leading to severe neurological and psychological symptoms or even death if not resolved quickly. Hori et al. use a whole-genome DNA microarray approach to characterise the molecular events of an ischemic episode in mice. The data confirm previous findings that inflammatory pathways are activated, but also show an up- or downregulation in the expression of many genes not previously associated with cerebral ischemia. This study provides new candidate genes and pathways for cerebral ischemia, as well as clues about endogenous factors that might prevent or reverse tissue damage. Page 270

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