The complexity of neuronal circuits presents a challenge when investigating potential future treatments for diseases caused by central nervous system defects. In a highly collaborative study from three groups at Harvard Medical School, Czupryn et al. show that transplanted neurons can establish neuronal circuitry in the mouse hypothalamus. This brain region controls aspects of whole-body metabolism, such as satiety and energy expenditure, in part by interpreting signals from the adipocyte-derived hormone leptin. To assess the potential to functionally repair complex neuronal circuitry, the authors transplanted fluorescently labelled leptin-responsive immature neurons and progenitors into db/db mice (which lack the leptin receptor, and are thus severely diabetic and morbidly obese). The transplanted cells localised to the hypothalamus, differentiated into the appropriate neuronal subtypes necessary for leptin signalling, functionally integrated, and led to amelioration of obesity and hyperglycemia. Thus, transplanted neurons can establish complex neural circuitry and restore defective physiological functions, suggesting great therapeutic potential for selected nervous system diseases.
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RESEARCH HIGHLIGHT| 01 January 2012
Functionally repairing complex synaptic circuitry
Online Issn: 1754-8411
Print Issn: 1754-8403
Written by editorial staff. © 2012. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
Dis Model Mech (2012) 5 (1): 2.
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Functionally repairing complex synaptic circuitry. Dis Model Mech 1 January 2012; 5 (1): 2. doi:
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