γ-secretase inhibitors (GSIs) block Notch pathway activation, which is thought to contribute to various epithelial cancers. Previous studies in the Apcmin mouse model of colon cancer suggest that GSIs inhibit intestinal neoplasia by converting proliferating cells into terminally differentiated goblet cells. Droy-Dupré et al. now assess the effects of a GSI called dibenzazepine (DBZ) in the intestines of healthy mice. They show that DBZ induces a homogenous goblet-cell conversion throughout the intestine, but that effects on intestinal-crypt-cell proliferation are heterogeneous. The authors propose that the effects of GSIs cannot be determined by goblet-cell conversion alone and encourage caution in the use of DBZ as a therapy. Page 107
Skip Nav Destination
IN THIS ISSUE| 01 January 2012
Effects of γ-secretase inhibitors in mouse colon
Online ISSN: 1754-8411
Print ISSN: 1754-8403
Written by editorial staff. © 2012. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
Dis Model Mech (2012) 5 (1): 1.
Effects of γ-secretase inhibitors in mouse colon. Dis Model Mech 1 January 2012; 5 (1): 1. doi:
Download citation file: