Ewing’s sarcoma is a malignant bone tumour often found in children and young adults. It is commonly caused by a chromosomal translocation resulting in the fusion protein EWS-FLI1, which is unique to tumour cells and therefore a candidate for targeted therapy. Leacock et al. are the first to report EWS-FLI1 transgenic zebrafish lines, which they use to shed new light on the function of this oncogenic fusion protein. Adult zebrafish with mosaic EWS-FLI1 expression develop tumours similar to human Ewing’s sarcoma, but zebrafish embryos expressing EWS-FLI1 exhibit developmental defects suggesting that EWS-FLI1 acts in part by suppressing non-canonical Wnt signalling. Page 95
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IN THIS ISSUE| 01 January 2012
Ewing’s sarcoma: transgenic zebrafish provide new clues
Online Issn: 1754-8411
Print Issn: 1754-8403
Written by editorial staff. © 2012. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
Dis Model Mech (2012) 5 (1): 1.
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Ewing’s sarcoma: transgenic zebrafish provide new clues. Dis Model Mech 1 January 2012; 5 (1): 1. doi:
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