Type 2 diabetes (T2D) and obesity are co-morbid metabolic disorders with increasing prevalence. Disease is linked to genetics in some individuals, but how dietary excess leads to the development of T2D is unclear. Musselman et al. report a new Drosophila model that permits close examination of factors linking a high-sugar diet with the development of obesity and insulin resistance. Fly larvae reared on excess sugars – but not those reared on excess fats or proteins – developed metabolic phenotypes resembling T2D. Many of the genes and pathways implicated in T2D in humans are also differentially expressed in flies reared on excess sugar. This system will be useful for high-throughput screens to identify genes and drug candidates that influence diet-induced insulin resistance. Page 842
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IN THIS ISSUE| 01 November 2011
Feeding frenzy: Drosophila model of type 2 diabetes
Online ISSN: 1754-8411
Print ISSN: 1754-8403
Written by editorial staff. © 2011. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
Dis Model Mech (2011) 4 (6): 709.
Feeding frenzy: Drosophila model of type 2 diabetes. Dis Model Mech 1 November 2011; 4 (6): 709. doi:
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