Regulating IGF1 bioavailability is crucial for normal development

Article navigation

IN THIS ISSUE| 01 September 2011

Regulating IGF1 bioavailability is crucial for normal development

Author and article information

Online ISSN: 1754-8411

Print ISSN: 1754-8403

2011

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

Dis Model Mech (2011) 4 (5): 557.

Insulin-like growth factor-1 (IGF1) has numerous biological roles. Its bioactivity is modulated by binding to IGF-binding proteins (IGFBPs) present in serum and tissues. Elis et al. studied the role of unbound (bioavailable) IGF1 in mouse strains expressing forms of IGF1 with low affinity for IGFBPs. They find that the mutant mice have increased body weight, length and relative lean mass, enlarged organs and enhanced mammary gland complexity. These data underscore the importance of tightly regulated IGF1 bioactivity for normal growth and development. Page 649

2011

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.