Insulin-like growth factor-1 (IGF1) has numerous biological roles. Its bioactivity is modulated by binding to IGF-binding proteins (IGFBPs) present in serum and tissues. Elis et al. studied the role of unbound (bioavailable) IGF1 in mouse strains expressing forms of IGF1 with low affinity for IGFBPs. They find that the mutant mice have increased body weight, length and relative lean mass, enlarged organs and enhanced mammary gland complexity. These data underscore the importance of tightly regulated IGF1 bioactivity for normal growth and development. Page 649
Skip Nav Destination
IN THIS ISSUE| 01 September 2011
Regulating IGF1 bioavailability is crucial for normal development
Online ISSN: 1754-8411
Print ISSN: 1754-8403
Written by editorial staff. © 2011. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
Dis Model Mech (2011) 4 (5): 557.
Regulating IGF1 bioavailability is crucial for normal development. Dis Model Mech 1 September 2011; 4 (5): 557. doi:
Download citation file: