Candida albicans is present as a benign commensal infection in more than 50% of the population but, in conditions of immune suppression, it can become a dangerous systemic infection with an estimated mortality rate of ∼30%. Despite its ubiquity, little is known about how host and pathogen interact during Candida infection. In two linked papers, the Ligoxygakis lab shows that the fruit fly Drosophila melanogaster is an appropriate model system both to rapidly assess virulence of Candida strains and to study systemic host responses. The tractability of Drosophila compared with mice makes it an attractive model to screen for host and pathogen factors involved in Candida infection, and for the development and testing of antifungal drugs.
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IN THIS ISSUE| 01 July 2011
Host-pathogen interactions in a fly model of C. albicans infection
Online ISSN: 1754-8411
Print ISSN: 1754-8403
Written by editorial staff. © 2011. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
Dis Model Mech (2011) 4 (4): 421.
Host-pathogen interactions in a fly model of C. albicans infection. Dis Model Mech 1 July 2011; 4 (4): 421. doi:
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