An important function of specialised epithelia is to regulate ion homeostasis. Dysfunction of epithelial ion homeostasis can give rise to several human diseases, such as distal renal acidosis (when kidney epithelia are affected) or cystic fibrosis (when lung and gut epithelia are affected). Dubaissi and Papalopulu investigate the use of Xenopus larval skin as a model to study epithelial ion homeostasis, and show that this tissue contains ionocytes that depend on the transcription factor foxi1e for development and are highly similar to intercalated cells of the human kidney. Furthermore, Xenopus ionocytes are required for normal development of multiciliated cells. This work demonstrates the utility of Xenopus larval skin as a model for investigating complex cell interactions in intact tissue.
Uncovering ionocytes in Xenopus epithelia
Uncovering ionocytes in Xenopus epithelia. Dis Model Mech 1 March 2011; 4 (2): 135. doi:
Download citation file:
Advertisement
Cited by
Call for Papers – Infectious Disease: Evolution, Mechanisms and Global Health
Showcase your latest research on our upcoming Special Issue: Infectious Disease: Evolution, Mechanisms and Global Health. This issue will be coordinated by DMM Editors Sumana Sanyal and David Tobin alongside Guest Editors Judi Allen and Russell Vance. The deadline for submitting articles to this Special Issue has been extended to Monday 24 February 2025.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate a DMM programme on antimicrobial resistance on 26 March 2025. Find out more and register to join us in March 2025 in Liverpool, UK.
The role of the International Society for Stem Cell Research guidelines in disease modelling
The International Society for Stem Cell Research (ISSCR) provides comprehensive guidelines and standards for using human stem cells in biomedical research. In this Editorial, Cody Juguilon and Joseph Wu discuss how and why these should be incorporated in disease modelling research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Other journals from
The Company of Biologists