Chemical mutagenesis approaches in zebrafish have created an important resource of mutant fish that have defects in organ development. Yee et al. demonstrate that a line of fish with abnormal pancreatic development carries a mutation in the ion channel receptor Trpm7. This protein is overexpressed in human pancreatic adenocarcinoma cell lines, and interfering with its expression inhibits cell growth, so it might be a potential biomarker and/or therapeutic target for pancreatic adenocarcinoma.
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IN THIS ISSUE| 01 March 2011
A role for Trpm7 in pancreatic cancer?
Online Issn: 1754-8411
Print Issn: 1754-8403
Written by editorial staff. © 2011. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
Dis Model Mech (2011) 4 (2): 135.
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A role for Trpm7 in pancreatic cancer?. Dis Model Mech 1 March 2011; 4 (2): 135. doi:
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