Understanding mechanisms of stem cell regulation is crucial for regenerative medicine as well as for new therapies for developmental defects and cancer. Using Xenopus laevis neural crest, an embryonic stem cell population, as a model system, Blackiston et al. show that modulating the bioelectrical state of a population of ‘instructor’ cells expressing the native glycine receptor chloride channel can trigger a neoplastic phenotype in other cells, an effect that is mediated by long-range serotonergic signalling. Modulating membrane voltage is therefore a potentially powerful therapeutic approach for manipulating stem cells.
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IN THIS ISSUE| 01 January 2011
Shock therapy: modulating stem cells
Online Issn: 1754-8411
Print Issn: 1754-8403
© 2011. Published by The Company of Biologists Ltd
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
Dis Model Mech (2011) 4 (1): 1.
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Shock therapy: modulating stem cells. Dis Model Mech 1 January 2011; 4 (1): 1. doi:
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