Enterohemorrhagic Escherichia coli (EHEC) O157:H7 infects only humans (causing acute gastroenteritis and hemorrhagic colitis) and calves. Because EHEC does not infect mice, simplified models that allow investigation of EHEC virulence mechanisms are urgently needed. Golan et al. now report a xenograft model involving transplantation of human and bovine intestinal segments into SCID mice that recapitulates several aspects of natural EHEC infection, including tissue tropism and typical histopathology. This model should allow further molecular studies of this important pathogen’s virulence.
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IN THIS ISSUE| 01 January 2011
Announcing a xenograft model of E. coli O157:H7
Online Issn: 1754-8411
Print Issn: 1754-8403
© 2011. Published by The Company of Biologists Ltd
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
Dis Model Mech (2011) 4 (1): 1.
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Announcing a xenograft model of E. coli O157:H7. Dis Model Mech 1 January 2011; 4 (1): 1. doi:
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