Amyotrophic lateral sclerosis (ALS) is a devastating and incurable neuromuscular disease. Identification of its causes, and development of effective treatments and drugs, are urgent priorities. Ramesh et al. describe a new zebrafish model, based on mutation of superoxide dismutase (SOD1), which recapitulates many aspects of the disease and should provide a powerful weapon for both basic research and drug discovery.
2010