Understanding how tumor-stromal interactions regulate the growth and metastasis of pancreatic ductal adenocarcinoma should help combat this aggressive cancer. Schluterman et al. report that grafted pancreatic tumors cannot grow properly in fibulin-5 knockout mice. Fibulin-5 normally sits in the extracellular matrix and prevents hyperactivation of integrin β1. Its loss triggers oxidative stress and apoptosis in the stromal microenvironment of the tumor, which withers away.
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IN THIS ISSUE| 28 April 2010
Elastin pancreatic tumors wilt for lack of fibulin-5
Online Issn: 1754-8411
Print Issn: 1754-8403
Dis Model Mech (2010) 3 (5-6): 255.
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Elastin pancreatic tumors wilt for lack of fibulin-5. Dis Model Mech 28 April 2010; 3 (5-6): 255. doi:
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