α-Synuclein (α-syn) is often mutated in neurological diseases, including Parkinson’s disease (PD), where it localizes to the Lewy bodies. Su, Auluck, Outeiro and colleagues find that yeast overexpressing α-syn alter their expression of mitochondrial-associated genes and exhibit abnormal mitochondrial function. In a chemical screen they identified compounds that reversed the adverse effects of α-syn on mitochondrial function, and ER-to-Golgi trafficking, in yeast and primary neurons from a rat model of PD.
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IN THIS ISSUE| 08 March 2010
Mitochondrial dysfunction in Parkinson’s disease
Online Issn: 1754-8411
Print Issn: 1754-8403
Dis Model Mech (2010) 3 (3-4): 121.
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Mitochondrial dysfunction in Parkinson’s disease. Dis Model Mech 8 March 2010; 3 (3-4): 121. doi:
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