In both humans and mice, high levels of the lipid phosphatase SHIP2 cause insulin resistance and susceptibility to type 2 diabetes, but the role of SHIP2 in cellular signalling is unclear. Jurynec and Grunwald show in zebrafish embryos that SHIP2 is an attenuator of the FGF signalling pathway, and that its loss causes many of the same phenotypes as exaggerated FGF signalling. The primary role of mammalian SHIP2 might therefore be to modulate endocrine FGF signalling, explaining its effects on metabolism.
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IN THIS ISSUE| 28 October 2010
SHIP2 modulates metabolism through FGF signalling
Online ISSN: 1754-8411
Print ISSN: 1754-8403
Dis Model Mech (2010) 3 (11-12): 663.
SHIP2 modulates metabolism through FGF signalling. Dis Model Mech 28 October 2010; 3 (11-12): 663. doi:
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