Li-Fraumeni syndrome (LFS) is a hereditary disease that is often associated with germline mutation of the tumor suppressor gene p53 and cancer. Parant and co-workers use a genetic screen in zebrafish to identify p53 mutant fish displaying a spectrum of tumors that closely mimics LFS. This approach may reveal new LFS genes, allow for whole-animal studies on the p53 pathway, and provide a rapid method for drug screening.
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IN THIS ISSUE| 14 January 2010
Li-Fraumeni zebrafish mutants
Online ISSN: 1754-8411
Print ISSN: 1754-8403
Dis Model Mech (2010) 3 (1-2): 1.
Li-Fraumeni zebrafish mutants. Dis Model Mech 14 January 2010; 3 (1-2): 1. doi:
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