The use of tyrosine kinase inhibitors (TKIs) to treat the 10–20% of lung adenocarcinomas with mutations in the EGFR gene is a recent success story in cancer medicine, but many tumors develop drug resistance after an initial response. Developing effective second-line therapy requires knowledge of the molecular basis of resistance, which is still unknown in many cases. Here, Katerina Politi and colleagues describe a mouse model of EGFR-induced lung tumors that, when treated with the TKI inhibitor erlotinib, become drug-resistant. This model will allow the mutations that cause resistance to be quickly identified and can also be used as a preclinical system to evaluate new therapeutic strategies. This research report is freely accessible online.
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IN THIS ISSUE| 14 January 2010
Drug-resistant lung cancers modeled in mice
Online Issn: 1754-8411
Print Issn: 1754-8403
Dis Model Mech (2010) 3 (1-2): 1.
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Drug-resistant lung cancers modeled in mice. Dis Model Mech 14 January 2010; 3 (1-2): 1. doi:
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