The use of tyrosine kinase inhibitors (TKIs) to treat the 10–20% of lung adenocarcinomas with mutations in the EGFR gene is a recent success story in cancer medicine, but many tumors develop drug resistance after an initial response. Developing effective second-line therapy requires knowledge of the molecular basis of resistance, which is still unknown in many cases. Here, Katerina Politi and colleagues describe a mouse model of EGFR-induced lung tumors that, when treated with the TKI inhibitor erlotinib, become drug-resistant. This model will allow the mutations that cause resistance to be quickly identified and can also be used as a preclinical system to evaluate new therapeutic strategies. This research report is freely accessible online.
Drug-resistant lung cancers modeled in mice
Drug-resistant lung cancers modeled in mice. Dis Model Mech 14 January 2010; 3 (1-2): 1. doi:
Download citation file:
Advertisement
Cited by
Special Issue: The RAS Pathway

Our latest special issue is now complete. It showcases RAS-driven mechanisms of disease progression, and highlights approaches to treat and modify the disease course in model systems.
Call for papers: Moving Heart Failure to Heart Success

Disease Models & Mechanisms is pleased to welcome submissions for consideration for an upcoming special issue, Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy. The deadline for submitting articles to the special issue has been extended to 1 August 2022.
Propose a new Workshop

Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country. .
A focus on Drosophila

In a series of front section articles, DMM is highlighting the versatility, breadth, and scope of Drosophila research in human disease modelling and translational medicine.
Apply for a DMM Conference Travel Grant

Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 6 June 2022. Find out more and hear from past recipients about their experience of the grant.
Other journals from
The Company of Biologists