Chronic allograft dysfunction (CAD) is a major problem in kidney transplant rejection. Using a mouse renal transplant model, Wang and co-workers show that inhibiting the innate immune system of the acceptor mouse, by knocking out the Toll-like receptor pathway, results in significantly healthier grafts. This research highlights the innate immune system as a possible focus for anti-CAD therapies.
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IN THIS ISSUE| 14 January 2010
Kidney transplants: innate immunity matters
Online ISSN: 1754-8411
Print ISSN: 1754-8403
Dis Model Mech (2010) 3 (1-2): 1.
Kidney transplants: innate immunity matters. Dis Model Mech 14 January 2010; 3 (1-2): 1. doi:
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