Xeroderma pigmentosum (XP) is an ultraviolet light-sensitivity syndrome caused by nucleotide excision repair (NER) defects, resulting in hyperpigmentation and an increased incidence of skin cancer. These symptoms also characterize the skin ‘telopathies’, which result from accelerated telomere shortening and exhaustion of the regenerative capacity of stem cells and lead to premature death. In this issue, Gerdine Stout and Maria Blasco investigate the pathways that connect stem cell dysfunction with telomere uncapping using a mouse model of telomere dysfunction which phenocopies the symptoms of XP patients. They demonstrate that both the absence of NER and the abrogation of p53 activity restore stem cell functionality. This work highlights the relationship between telomeres and stem cell renewal with the pathobiology of cancer.
Call for papers – In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery
We invite you to submit your latest research to our upcoming special issue: In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery, coordinated by DMM Editor Vivian Li (The Francis Crick Institute, London, UK), alongside Guest Editors Austin Smith (University of Exeter, UK) and Joseph Wu (Stanford University School of Medicine, USA).The deadline for submitting articles is 6 October 2025.
The Company of Biologists Workshops
For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Fast & Fair peer review
Our sister journal Biology Open has recently launched the next phase of their Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. To learn more about BiO’s progress and future plans, read the Editorial by Daniel Gorelick, or visit the Fast & Fair peer review page.
Propose a new Workshop for 2027
We are currently seeking proposals for Workshops to be held in 2027. As one of the scientific organisers of a The Company of Biologists Workshop, your involvement will be focused on interdisciplinary, cutting-edge science and promoting new partnerships and collaborations. We focus on the logistics. Are you thinking about proposing a topic for one of our Workshops? Apply by Friday 30 May 2025.
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