This article includes recent preLights posts that discuss preprints in the field of disease biology.
Featured preLight
RIPK3 coordinates RHIM domain-dependent inflammatory transcription in neurons by Sigal B. Kofman et al.
Detection of MLKL protein by immunofluorescent staining and analysis in untransduced or AAV6-MND-MLKL transduced Mox2cre+Ripk3-2xFVLSL neurons 24 hours after B/B treatment. Figure 3C from Kofman et al. (BioRxiv) published under a CC-BY-NC-ND 4.0 International license.
preLighter(s)
Zoie Magri, PhD student at Tufts Graduate School of Biomedical Sciences, Boston, United States
Why it was selected
“This preprint is important because it shows a novel mechanism in which neurons participate in an immune response. As they are incapable of removing a viral niche via cell death, one may consider them a vulnerable cell population. However, this work demonstrates that neurons are able to co-opt existing pro-death proteins, that are activated by a virus, to induce an antiviral response. While the neurons cannot eliminate themselves as a replicative niche, RIPK3 allows them to create an anti-viral environment via cytokines. Additionally, this work validates the potential targeting of RIPK3 and other RHIM-containing proteins in preventing or reducing neuroinflammation in viral or pathological contexts.”
Other relevant preLight posts
Control of Inflammatory Response by Tissue Microenvironment by Zhongyang Wu et al.
Macrophages sense the environment to tune inflammation.
Selected by Roberto Amadio. Read the preLight.
Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility by Kate E. McCluskey et al.
Taking back control of the gut - how Autism Spectrum Disorders dysregulate the gut, and what we can do about it.
Selected by Rachel Mckeown. Read the preLight.
LINC complex alterations are a hallmark of sporadic and familial ALS/FTD by Riccardo Sirtori et al.
The missing link between ALS and nuclear deformation? It's the missing LINC.
Selected by Megane Rayer and Rivka Shapiro and preLights peer support. Read the preLight.
G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics by Alexandra Mazharian et al.
The CAPRI sun rises: new bispecific antiplatelet agents for targeted inhibition of signalling through GPVI or CD32A.
Selected by Simon Cleary. Read the preLight.
Feedback loop regulation between viperin and viral hemorrhagic septicemia virus through competing protein degradation pathways by Xiaobing Lu et al.
Viperin and viral hemorrhagic septicemia virus take advantage of feedback regulation through competing protein degradation pathways.
Selected by UofA IMB565 and Paige Sandoval and Fahmida Alam and Hriday Sutradhar. Read the preLight.
Lytic bacteriophages interact with respiratory epithelial cells and induce the secretion of antiviral and proinflammatory cytokines by Paula F. Zamora et al.
Phage therapy FTW!💥 But be warned, the vibes that these efficient bacterial killers have with human cells can vary!🧫 Get the scoop on these micro-warriors!💊 #PhageRevolution
Selected by UofA IMB565 and Riley Hellinger and Yash Sharma. Read the preLight.
Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects by Ritobrata Ghose et al.
What doesn't kill them makes them stronger: cancer cells under confinement.
Selected by Teodora Piskova. Read the preLight.
PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in hepatocytes by Binayak Sarkar et al.
TBDisseminated: the importance of PPARy and lipid biogenesis in disseminated tuberculosis infection.
Selected by UofA IMB565 and Nicholas Cusick and Sloane McVicker and Sydney Verdugo. Read the preLight.
Aspergillus dsRNA virus drives fungal fitness and pathogenicity in the mammalian host by Vanda Lerer et al.
A mycovirus could be the Achilles Heel of Aspergillus fumigatus; curing it could cure us.
Selected by UofA IMB565 and Jennifer Uhrlaub and Christina Arnoldy and Anh Evy Nguyen. Read the preLight.
14-3-3 binding regulates Tau assembly and microtubule association by Janine Hochmair et al.
14-3-3 and Tau have a molecular situationship - only specific interactions prevent a tangled protein mess.
Selected by Barbora Knotkova and Jannik Faierson and preLights peer support. Read the preLight.
Fetal brain response to maternal inflammation requires microglia by Bridget Elaine LaMonica Ostrem et al.
Microglia connect maternal immune activation to adverse fetal brain development.
Selected by Manuel Lessi. Read the preLight.
Transcriptional profiling of human brain cortex identifies novel lncRNA-mediated networks dysregulated in amyotrophic lateral sclerosis by Alessandro Palma, Monica Ballarino
Not long ago classified as “junk genetic material”, non-coding RNA's real role in cellular regulation becomes more apparent one paper at a time. In this preprint, the authors uncover the role of several long non-coding RNAs in ALS.
Selected by Julio Molina Pineda. Read the preLight.
A complex Plasmodium falciparum cryptotype circulating at low frequency across the African continent by Olivo Miotto et al.
An unexpectedly differentiated group of parasites was found within Plasmodium samples across Africa.
Selected by Alejandra Herbert Leffler's Lab. Read the preLight.
Plasmodium RON11 triggers biogenesis of the merozoite rhoptry pair and is essential for erythrocyte invasion by David Anaguano et al.
An unusual single-rhoptry phenotype caused by the depletion of RON11 in Plasmodium parasites.
Selected by Sara Chelaghma. Read the preLight.
Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis thymoma by Yoshiaki Yasumizu et al.
New hope for Myasthenia Gravis Thymoma patients.
Selected by Jessica Chevallier. Read the preLight.
Evolution of tandem repeats in putative CSP to enhance its function: A recent and exclusive event in Plasmodium vivax in India by Manoswini Dash et al.
Is variation in repeats driving PVX_086150 evolution?
Selected by Alejandra Herbert Leffler's Lab. Read the preLight.
DNA methylation enables recurrent endogenization of giant viruses in an animal relative by Luke A. Sarre et al.
Methylation silences giant virus DNA in Amoebidium.
Selected by Jennifer Ann Black. Read the preLight.
Behavioral screening of conserved RNA-binding proteins reveals CEY-1/YBX RNA-binding protein dysfunction leads to impairments in memory and cognition by Ashley N Hayden et al.
Forgetful worms shed light on human neurological disorders.
Selected by Chee Kiang Ewe. Read the preLight.
Prenatal inflammation reprograms hyperactive ILC2s that promote allergic lung inflammation and airway dysfunction by Diego A. López et al.
ILC you on the other side – how prenatal inflammation remodels the immune landscape in offspring.
Selected by Marina Schernthanner. Read the preLight.
Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets by John M. Bennett et al.
Lessons from nature for antimalarial agent discovery: John M. Bennett and colleagues develop serine hydrolase inhibitors targeting plasmodium parasites.
Selected by Zhang-He Goh. Read the preLight.
