This article includes recent preLights posts that discuss preprints in the field of disease biology.
Featured preLight
Prenatal inflammation reprograms hyperactive ILC2s that promote allergic lung inflammation and airway dysfunction by Diego A. López et al.
Artistic representation of a human lung. Created by Reinier Prosée.
preLighter(s)
Marina Schernthanner, PhD student at The Rockefeller University, New York City, United States
Why it was selected
“The preprint by López and colleagues adds insights into how prenatal inflammation shapes the immune repertoire of another important barrier site—the lung. In a world where child-borne diseases—with allergies and asthma leading the way—become more and more prevalent, it is crucial to not only gain a better understanding of the underlying causes, but also shed light on how the immune system changes—evolves—over time. Given the highly plastic nature of several immune subsets during the neonatal window, distinct antigen exposure and infection during that period may predispose individuals to chronic respiratory disease. This preprint pinpoints prenatal inflammation and subsequent allergen exposure after birth as an example of that, highlighting ILCs in the lung as an instrumental player in establishing lung pathology. Taking a holistic approach and studying evolving immune populations as they adapt to their tissue of residence (and crosstalk with cells in their microenvironment) appears to be important in understanding chronic respiratory diseases. It also demarcates areas of research that I am personally very excited about.”
Other relevant preLight posts
Behavioral screening of conserved RNA-binding proteins reveals CEY-1/YBX RNA-binding protein dysfunction leads to impairments in memory and cognition by Ashley N Hayden et al.
Forgetful worm sheds lights on human neurological disorders.
Selected by Chee Kiang Ewe. Read the preLight.
Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2 by Chrystian Junqueira Alves et al.
An axon guidance protein moonlights as a mechanosensitive regulator of tumour invasion: Alves and colleagues demonstrate Plexin-B2's key role in confined cell migration.
Selected by Jade Chan. Read the preLight.
Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets by John M. Bennett et al.
Lessons from nature for antimalarial agent discovery: John M. Bennett and colleagues develop serine hydrolase inhibitors targeting plasmodium parasites.
Selected by Zhang-He Goh. Read the preLight.
2D and 3D multiplexed subcellular profiling of nuclear instability in human cancer by Shannon Coy et al.
Nuclear ruptures: no longer BAF-fling? Coy and colleagues use multiplexed imaging techniques to capture nuclear atypia in human cancers.
Selected by Jade Chan. Read the preLight.
Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair by Marieke R. Wensveen et al.
Histone demethylase dUtx safeguards facultative heterochromatin integrity in response to DNA breaks.
Selected by Pierre Caron. Read the preLight.
The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity by Hasan Mamar et al.
POLE4: how to make cancer cells more sensitive to treatment.
Selected by Audrey Noireterre. Read the preLight.
