Featured preLight
Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness by Dominik Koessinger et al.
A schematic outlining the EV-mediated crosstalk between GBM cells and astrocytes. Schematic created by Jade Chan and Reinier Prosée.
preLighter
Jade Chan, Graduate Student at the University of Toronto, Toronto, Canada
Why it was selected
“[Glioblastoma (GBM)] is notoriously infiltrative, which contributes to its near-universal recurrence following surgery. I chose this preprint because it illustrates a complete signalling axis wherein GBM cells influence their neighbouring cell types into fuelling their invasion into healthy brain tissue. I am currently investigating the role of a specific protein in adhesion-dependent versus adhesion-independent migration in GBM. This preprint, along with other studies examining the crosstalk between tumour cells and their microenvironment, have inspired me to look beyond cell-autonomous factors that influence GBM cell invasion. Looking into microenvironmental relationships may be important for developing new therapies since GBM cells are highly heterogeneous.”
Other relevant preLight posts
Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant by Nanami Senoo et al.
Reduced power supply without cardiolipin: mechanisms behind a mitochondrial myopathy mutation in the ADP/ATP carrier revealed.
Selected by Barbora Knotkova. Read the preLight.
Subchronic alteration of vestibular hair cells in mice: implications for multisensory gaze stabilization by Louise Schenberg et al.
When mice receive unreliable information from their ears, how do they use their eyes? Schenberg et al. show that visual reflexes are altered and can supplement info during vestibular stimulation.
Selected by Samantha Davis. Read the preLight.
Nociceptor neuroimmune interactomes reveal cell type- and injury-specific inflammatory pain pathways by Aakanksha Jain et al.
Discovering the hidden connections between neurons and immune cells in pain perception.
Selected by Patrick Penndorf. Read the preLight.
Improving anxiety research: novel approach to reveal trait anxiety through summary measures of multiple states by Zoltan K Varga et al.
Anxious rodents for the better understanding of human anxiety.
Selected by Nándor Lipták. Read the preLight.
Coxiella burnetii actively blocks IL-17-induced oxidative stress in macrophages by Tatiana M. Clemente et al.
Coxiella burnetii, the pathogen that causes Q fever, demonstrates a strategy to effectively evade the immune system by inhibiting the IL-17-induced oxidative stress in macrophages. preLight Authors: Abigail Page & Farhana Afrin Mohona.
Selected by UofA IMB565. Read the preLight.
Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance by Marinelle Rodrigues et al.
A new model for antibiotic treatment research uncovers an unorthodox method for bacterial survival of treatment. preLight Authors: Hannah Brooks & Derek Resio.
Selected by UofA IMB565. Read the preLight.
Inhibition of Cellular MEK/ERK Signaling Suppresses Murine Papillomavirus Type 1 Replicative Activities and Promotes Tumor Regression by Adrian J. Luna et al.
How to fight HPV-induced cancer? In this preprint, Luna et al. investigated this possibility by testing two clinically approved drugs to stop HPV at its early replication stage.
Selected by Yvonne Xinyi Lim. Read the preLight.
A survey of rare disease awareness among healthcare professionals and researchers in India by Laxmikant Vashishta et al.
Survey identifies opportunities to improve RD awareness and knowledge among healthcare professionals and researchers in India.
Selected by Preethi Krishnaraj. Read the preLight.
Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing by Fumiyuki Hatanaka et al.
Gene correction alone is not sufficient to treat spinal muscular atrophy (SMA). But combining gene editing with gene supplementation shows a more significant benefit in a mouse model of SMA.
Selected by Preethi Krishnaraj. Read the preLight.
Inhibition of Centrosome Clustering Reduces Cystogenesis and Improves Kidney Function in Autosomal Dominant Polycystic Kidney Disease by Tao Cheng et al.
Fighting the “Cyst”em through inhibition of centrosome amplification in polycystic kidney disease.
Selected by Fiona Macleod. Read the preLight.
Flat clathrin lattices are linked to metastatic potential in colorectal cancer by Charlotte Cresens et al.
It's dangerous to be sticky – adhesive plasma membrane structures are associated with metastatic potential in colorectal cancer.
Selected by Emily Chan. Read the preLight.
Humoral and T-cell-mediated responses to a pre-clinical Zika vaccine candidate that utilizes a unique insect-specific flavivirus platform by Danielle L. Porier et al.
How do you balance vaccine safety with a robust immune response? One group is using an insect-specific viral backbone that cannot infect mammals in their studies of a potential vaccine for Zika virus.
Selected by Lucy Bowden. Read the preLight.
