There were errors in Dis. Model. Mech. (2010) 3, dmm002311 ().
All semi-quantitative RT-PCR data for SREBP-1c, ACC1, FAS, PPARA, CPT1, ACO1 and β-actin shown in the original Fig. 3E and Fig. 4E represent cropped images of a single set of gels. However, during figure assembly, some images were cropped incorrectly, leading to discrepancies among the images shown.
Specifically, there were errors in assembly of the SREBP-1c (Fig. 4E, top), FAS (Fig. 3E, left), CPT1 (Fig. 4E, bottom) and β-actin (Fig. 3E, left; Fig. 4E, top and bottom) gels. The authors have provided the corrected versions of these panels as a single figure. All citations to Fig. 3E and Fig. 4E in the main text should now refer to this new panel.
(E) Altered expression of lipogenic and lipolytic genes. mRNA levels of the indicated genes in livers from control (lanes 1 and 2), HFD-medaka (lanes 3 and 4), and HFD+EPA medaka (lanes 5 and 6) at 4 weeks were determined by semi-quantitative RT-PCR. SREBP-1c, ACC1 and FAS were all elevated in HFD-medaka compared with their levels in control medaka. Conversely, the mRNA levels of PPARA and CPT1 were reduced and those of ACO1 were increased. Compared with HFD-medaka, the mRNA levels of SREBP-1c, ACC1 and FAS were reduced in HFD+EPA medaka. Conversely, the expression levels of PPARA and CPT1 were increased in HFD+EPA medaka, whereas the level of ACO1 was decreased. This pattern also resembled that observed in medaka that were fed the control diet (n=6/group).
(E) Altered expression of lipogenic and lipolytic genes. mRNA levels of the indicated genes in livers from control (lanes 1 and 2), HFD-medaka (lanes 3 and 4), and HFD+EPA medaka (lanes 5 and 6) at 4 weeks were determined by semi-quantitative RT-PCR. SREBP-1c, ACC1 and FAS were all elevated in HFD-medaka compared with their levels in control medaka. Conversely, the mRNA levels of PPARA and CPT1 were reduced and those of ACO1 were increased. Compared with HFD-medaka, the mRNA levels of SREBP-1c, ACC1 and FAS were reduced in HFD+EPA medaka. Conversely, the expression levels of PPARA and CPT1 were increased in HFD+EPA medaka, whereas the level of ACO1 was decreased. This pattern also resembled that observed in medaka that were fed the control diet (n=6/group).
This correction does not affect the results in the article or the conclusions of this study. The authors apologise for these errors and any inconvenience they may have caused.
