Loss of epithelial polarity redirects Notch signaling and triggers a Xrp1 response during neoplastic growth in Drosophila by Logeay et al.
Invasive Procedure: new insights into how changes in epithelial structure can turn Notch nasty.
Selected by Sally Lowell. Read the guest preLight here
The WD and linker domains of ATG16L1 required for non-canonical autophagy limit lethal influenza A virus infection at epithelial surfaces by Wang et al.
Loss of non-canonical autophagy in mice increases sensitivity to influenza A virus infection by disrupting defences at the lung epithelial barrier, but not in phagocytic leukocytes.
Selected by Kirsty Hooper. Read the preLight here
Bariatric surgery reveals a gut-restricted TGR5 agonist that exhibits anti-diabetic effects by Chaudhari et al.
A gut check for bariatric surgery – Surgery-mediated bile acid changes improve metabolic parameters.
Selected by Connor Rosen. Read the preLight here
NINJA: an inducible genetic model for creating neoantigens in vivo by Damo et al.
A neoantigen in disguise, the NINJA system: testing the functionality of a novel genetically engineered mouse model with an inducible neoantigen construct.
Selected by Deborah Caswell. Read the preLight here
Obesity-driven changes in ECM composition promote local invasion and metastasis of breast tumors by Wishart et al.
Obesity and breast cancer – Collagen VI in the spotlight
Selected by Vassilis Papalazarou and Anh Hoang Le. Read the preLight here
Regeneration in the adult Drosophila brain by Crocker et al.
A hidden stem cell-like population found in the Drosophila brain: let's regenerate.
Selected by Ivana Viktorinová. Read the preLight here
On-demand spatiotemporal programming of collective cell migration via bioelectric stimulation by Zajdel et al.
An electricity-based pied piper of Hamelin: moving cells on demand.
Selected by Mariana De Niz. Read the preLight here
Mutational signatures are jointly shaped by DNA damage and repair by Volkova et al.
A combinatory mutational screen in C. elegans, combining 54 DNA repair mutants and 12 genotoxins, demonstrates that mutations are a result of both DNA damage and failed repair.
Selected by Kerryn Elliott. Read the preLight here
Chemogenetic analysis of how receptors for short chain fatty acids regulate the gut-brain axis by Barki et al.
Following your gut – using chemogenetics to understand how short chain fatty acids regulate the gut-brain axis.
Selected by Phyllis Phuah. Read the preLight here
