Single-cell gene regulatory network analysis reveals new melanoma cell states and transition trajectories during phenotype switching by Wouters et al.
This new preprint from the Aerts lab details how they used scRNA-seq to identify a new intermediate cell state during melanoma phenotype switching.
Selected by Hannah Brunsdon. Read the preLight here
Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease by Wheeler et al.
Not a big FUS over nothing: small molecules altering phase behavior of stress granules emerge as an effective method to reduce aggregation and reverse ALS-associated phenotypes.
Selected by Madhuja Samaddar. Read the preLight here
Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types by Miar et al.
Through the I of cancer; Immunosuppression via the hypoxic downregulation of IFN in multiple cancer cell types.
Selected by Jonny Coates. Read the preLight here
Single-cell RNA-sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis by Habermann et al.
AND
Single Cell RNA-seq reveals ectopic and aberrant lung resident cell populations in Idiopathic Pulmonary Fibrosis by Adams et al.
The application of single cell RNA sequencing (scRNAseq) approaches in the context of idiopathic pulmonary fibrosis (IPF) highlights dramatic remodelling of epithelial, stromal and vascular transcriptomes.
Correction of Niemann-Pick type C1 disease with the histone deacetylase inhibitor valproic acid by Subramanian et al.
Old Dogs Can Learn New Tricks: using existing therapeutic compounds to treat Niemann-Pick type C disease.
Selected by Joanna Cross. Read the preLight here
Cross-species transcriptomic and epigenomic analysis reveals key regulators of injury response and neuronal regeneration in vertebrate retinas by Hoang et al.
Fish can fully regenerate cells in the eye after an injury, the chick can do it partially, while mammals lack regenerative potential. The Blackshaw lab explores the pathways activated upon retinal injury in these species.
Selected by Sejal Davla. Read the preLight here
Aging is associated with a systemic length-driven transcriptome imbalance by Stoeger et al.
A systems biology approach points to an imbalance in RNA transcript length as the best single factor implicated in ageing, more significant than any gene alteration alone.
Selected by Monika Magon. Read the preLight here
Quantitative intravital imaging of Plasmodium falciparum sporozoites: A novel platform to test malaria intervention strategies by Hopp et al.
One for all: IVM shows comparable dynamics of human and rodent Plasmodium sporozoites in murine skin, offering a promising tool to investigate anti-malarial intervention targeting sporozoites at the point of inoculation.
Selected by Mariana De Niz. Read the preLight here
