Adipocyte vesicles: ‘all-in-one’ packages that stimulate tumor mitochondrial metabolism and dynamicsby Clement et al.

Adipocytes donate packets of energy to melanoma cells to stimulate their mitochondrial metabolism and fuel cell motility.

Selected by Hannah Brunsdon. Read the preLight here

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug screeningby Mastikhina et al.

Molecular and functional features of cardiac fibrosis pathogenesis recapitulated in vitro: a novel microwell device suited for drug testing.

Selected by Hiroyoshi Y. Tanaka. Read the preLight here

Liver-Chip: Reproducing Human and Cross-Species Toxicitiesby Jang et al.

I’ll have Liver-Chips with that: researchers apply rat, dog, and human liver cells to organ-on-chip technology.

Selected by Zhang-He Goh. Read the preLight here

Modulation of neuronal resilience during aging by Hsp70/Hsp90/STI1 chaperone systemby Lackie et al.

The chaperone network as a highway to tissue resilience: the Hsp70/Hsp90 machinery prevents age-dependent hippocampal neurodegeneration.

Selected by Giuliana Clemente. Read the preLight here

Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanismby Bouagnon et al.

The Hunger Games: Peroxisomes are the central metabolic hubs that integrate metabolic status with the serotonergic signaling of feeding behaviour and fat metabolism.

Selected by Pablo Ranea Robles. Read the preLight here

Integrated Metabolomic and Transcriptomic Profiling Reveals Novel Activation-Induced Metabolic Networks in Human T cellsby Hiemer et al.

Feeding immunity: TCR stimulation leads to metabolic rewiring in human T cells to promote glucose and amino acid metabolism.

Selected by Jonny Coates. Read the preLight here

Benchmarking Single-Cell RNA Sequencing Protocols for Cell Atlas Projectsby Mereu et al.


Systematic comparative analysis of single cell RNA-sequencing methodsby Ding et al.

RNAseq is now a practical, high-throughput and economically viable approach to determine cell fate and state at single cell resolution. As consortia form to generate tissue/organ ‘atlases’, these preprints compare RNA sequencing techniques.

Selected by Rob Hynds. Read the preLight here

High-throughput mapping of mesoscale connectomes in individual miceby Huang et al.

Behavior can vary widely among individuals. A recent study developed a commanding technique to reconstruct whole-cortex connectomes using a single animal, with ensuing applications for measuring individual variability in neuronal wiring.

Selected by Dena Goldblatt. Read the preLight here

OptiJ: Open-source optical projection tomography of large organ samplesby Ramirez et al.

A tool for all- OptiJ: an easy-to-assemble setup and freely available software as an incentive for widescale implementation of OPT.

Selected by Mariana De Niz. Read the preLight here

Precisely control mitochondria with light to manipulate cell fate decisionby Ernst et al.

Using optogenetics, the ‘method of the decade’, to depolarise mitochondria.

Selected by Amberley Stephens. Read the preLight here