Adipocyte vesicles: ‘all-in-one’ packages that stimulate tumor mitochondrial metabolism and dynamics by Clement et al.
Adipocytes donate packets of energy to melanoma cells to stimulate their mitochondrial metabolism and fuel cell motility.
Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug screening by Mastikhina et al.
Molecular and functional features of cardiac fibrosis pathogenesis recapitulated in vitro: a novel microwell device suited for drug testing.
Liver-Chip: Reproducing Human and Cross-Species Toxicities by Jang et al.
I’ll have Liver-Chips with that: researchers apply rat, dog, and human liver cells to organ-on-chip technology.
Modulation of neuronal resilience during aging by Hsp70/Hsp90/STI1 chaperone system by Lackie et al.
The chaperone network as a highway to tissue resilience: the Hsp70/Hsp90 machinery prevents age-dependent hippocampal neurodegeneration.
Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanism by Bouagnon et al.
The Hunger Games: Peroxisomes are the central metabolic hubs that integrate metabolic status with the serotonergic signaling of feeding behaviour and fat metabolism.
Integrated Metabolomic and Transcriptomic Profiling Reveals Novel Activation-Induced Metabolic Networks in Human T cells by Hiemer et al.
Feeding immunity: TCR stimulation leads to metabolic rewiring in human T cells to promote glucose and amino acid metabolism.
Benchmarking Single-Cell RNA Sequencing Protocols for Cell Atlas Projects by Mereu et al.
Systematic comparative analysis of single cell RNA-sequencing methods by Ding et al.
RNAseq is now a practical, high-throughput and economically viable approach to determine cell fate and state at single cell resolution. As consortia form to generate tissue/organ ‘atlases’, these preprints compare RNA sequencing techniques.
High-throughput mapping of mesoscale connectomes in individual mice by Huang et al.
Behavior can vary widely among individuals. A recent study developed a commanding technique to reconstruct whole-cortex connectomes using a single animal, with ensuing applications for measuring individual variability in neuronal wiring.
OptiJ: Open-source optical projection tomography of large organ samples by Ramirez et al.
A tool for all- OptiJ: an easy-to-assemble setup and freely available software as an incentive for widescale implementation of OPT.
Precisely control mitochondria with light to manipulate cell fate decision by Ernst et al.
Using optogenetics, the ‘method of the decade’, to depolarise mitochondria.