3D microenvironment stiffness regulates tumor spheroid growth and mechanics via p21 and ROCK by Taubenberger et al.
Tuning and probing the stiffness of 3D microenvironments for interrogating its mechanical impact on tumour spheroid growth.
Selected by Jacky Goetz. Read the preLight here
Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies by Gurbatri et al.
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Programmable bacteria induce durable tumor regression and systemic antitumor immunity by Chowdhury et al.
Getting bacteria to do our dirty work: Tal Danino and colleagues develop bacterial platforms to fight cancer.
Selected by Pavithran Ravindran. Read the preLight here
Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer's disease by Lambeth et al.
Do LSDs have the answer? Exploring a promising link between lysosomal storage disorders and Alzheimer's disease.
Selected by Joanna Cross. Read the preLight here
Transcriptome analysis of Plasmodium berghei during exo-erythrocytic development by Caldelari et al.
How is the Plasmodium parasite's progeny different in the liver and the blood? A transcriptomic study provides clues and implications for pathology.
Selected by Mariana De Niz. Read the preLight here
AGO1x prevents dsRNA-induced interferon signaling to promote breast cancer cell proliferation by Ghosh et al.
When do stop signs become optional? Ghosh et al. report an important role for an AGO1 isoform generated by translational readthrough.
Selected by Lorenzo Lafranchi. Read the preLight here
Tousled-like kinase activity is required for transcriptional silencing and suppression of innate immune signalling by Segura-Bayona et al.
Tousled-like kinase activity - an intricate connection between heterochromatin assembly, genome instability and innate immune responses.
Selected by Yasmin Lau. Read the preLight here
Intravital optoacoustic ultrasound bio-microscopy reveals radiation-inhibited skull angiogenesis by Estrada et al.
Shedding light on skull and cerebral vascular changes: optoacoustic ultrasound bio-imaging shows irradiation effects on angiogenesis inhibition.
Selected by Mariana De Niz. Read the preLight here
Specific Disruption of Established P. aeruginosa Biofilms Using Polymer-Attacking Enzymes by Kovach et al.
Weakening the Fence: Polymer specific enzymes for biofilm matrix degradation.
Selected by Snehal Kadam. Read the preLight here
A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila by Port et al.
Bringing CRISPR to the masses: New tools for in vivo genome editing in flies.
Selected by Gabriel Aughey. Read the preLight here
Co-reviewing and ghostwriting by early career researchers in the peer review of manuscripts by McDowell et al.
Ghost in the machine: widespread uncredited participation by early career researchers in peer review raises ethical flags, but provides opportunities for change.
Selected by Gautam Dey and Tessa Sinnige. Read the preLight here
