Senescence of alveolar stem cells drives progressive pulmonary fibrosis by Yao et al.
In pulmonary fibrosis, alveolar type II stem cells become senescent. In a mouse model, genetic induction of senescence in this population was sufficient to cause TGFβ-dependent progressive fibrosis, in contrast to existing rapidly resolving models.
Colibactin DNA damage signature indicates causative role in colorectal cancer by Dziubańska-Kusibab et al.
A Bacterial Toxin Finds Its Target – Colibactin Sequence Recognition and Mutational Signatures in Cancer
Selected by Connor Rosen. Read the preLight here
Identification of neural oscillations and epileptiform changes in human brain organoids by Samarasinghe et al.
Excitatory/inhibitory fusion organoids OSCILLATE! In combination with iPSC technology this allows patient specific drug tailoring, as exemplified by Rett Syndrome in this preprint.
Selected by Theresa Pohlkamp. Read the preLight here
A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses by Okkelman et al.
Shedding light on unique metabolic properties of the Lgr5+ stem cell niche by O2 phosphorescence & NAD(P)H fluorescence imaging of intestinal organoids.
Selected by Jessica Xie. Read the preLight here
Multiple overlapping hypothalamus-brainstem circuits drive rapid threat avoidance by Lovett-Barron et al.
Stressed? The hypothalamus in action again, but it's complicated! Lovett-Barron et al. investigate the brain areas controlling stress-induced avoidance behaviour.
Selected by Amrutha Swaminathan and Rudra Nayan Das. Read the preLight here
Alteration of cardiolipin-dependent mitochondrial coupling in muscle protects against obesity by Prola et al.
A mitochondrial defect with unexpected consequences. Reduced cardiolipin content in mitochondrial membranes impairs phosphorylating respiration but protects Hacd1-deficient mice against diet-induced obesity.
Selected by Pablo Ranea Robles. Read the preLight here
Subcellular mRNA localization regulates ribosome biogenesis in migrating cells by Dermit et al.
Take me to the tip- localized translation of ribosomal proteins at cell protrusions governs cancer metastasis.
Selected by Nidhi Kanwal. Read the preLight here
Epigenetic gene silencing by heterochromatin primes fungal resistance by Torres-Garcia et al.
Yeast chromatin high on caffeine! Torres-Garcia and colleagues describe a heritable heterochromatin-based response underlying resistance to moderate caffeine levels.
Selected by Miguel V. Almeida. Read the preLight here
bioRxiv: the preprint server for biology by Sever et al.
More than 64,000 research articles have been shared through the life sciences preprint server bioRxiv as changes in the scientific publication landscape gather pace.
Selected by Jonny Coates and Rob Hynds. Read the preLight here
