HSP110 dependent HSP70 disaggregation machinery mediates prion-like propagation of amyloidogenic proteins in metazoa by Tittelmeier et al.
Two sides of the same coin: Hsp110 activity protects against amorphous protein aggregation, but promotes amyloid aggregation and toxicity in C. elegans models.
Tumors Exploit Dedicated Intracellular Vesicles to Program T cell Responses by Roberts et al.
Dendritic cells bring enough to share: cell-cell transfer of tumor antigens in lymph nodes.
Ephrin-B1 blocks adult cardiomyocyte proliferation and heart regeneration by Cauquil et al.
A new link between CM rod shape and proliferation - Ephrin B1 sequestration of Yap1 at the lateral membrane.
Single Cell Gene Expression Analysis Reveals Human Stem Cell-Derived Graft Composition in a Cell Therapy Model of Parkinson's Disease by Tiklová et al.
What's in my graft? Single-cell RNAseq comparison of fetal midbrain and stem cell-derived dopamine neuron progenitors transplanted into Parkinson's disease model rats shows many similarities and several COLorful differences!
Axon-like protrusions promote small cell lung cancer migration and metastasis by Yang et al.
Neuron+cancer cell=deadly combination! Yang et al. find that cancers that exhibit a neuronal phenotype metastasize more.
Mechanotransduction of strain regulates an invasive phenotype in newly transformed epithelial cells by Chagnon-Lessard et al.
How the everyday movement of tissues affects cell-cell interactions and the initiation of cancer.
Cerebellar Purkinje cell microcircuits are essential for tremor by Brown et al.
Be on good talking terms with your neighbours, or things could go south. In the brain, bad conversations between Purkinje cells and their immediate neighbours, the cerebellar nuclei, can cause tremors.
Coexistence with Pseudomonas aeruginosa alters Staphylococcus aureus transcriptome, antibiotic resistance and internalization into epithelial cells by Briaud et al.
Friends with benefits: Mutualism between Pseudomonas aeruginosa and Staphylococcus aureus in Cystic Fibrosis patients.
GeneWalk identifies relevant gene functions for a biological context using network representation learning by Ietswaart et al.
Fear the Walking Gene: knowledge-based machine learning is able to highlight gene functions relevant for a distinct biological context.
The enteric nervous system of the human and mouse colon at a single-cell resolution by Drokhlyansky et al.
Meet the 1%: single-cell RNAseq of human & mouse enteric nervous system reveals core transcriptional programs of enteric neurons, DEGs by circadian phase & colon location, new models for intestinal peristalsis, neuro-immune interactions, and more!
Variant antigen diversity in Trypanosoma vivax is not driven by recombination by Pereira et al.
Do we know enough about Trypanosome spp. mechanisms of antigenic variation? T. vivax challenges our current understanding of variant antigen diversity.
COMET: A toolkit for composing customizable genetic programs in mammalian cells by Donahue et al.
Reaching for the shooting stars: a COMET toolkit for bespoke mammalian cell genetic programming.