Basal extrusion drives cell invasion and mechanical stripping of E-cadherin by Fadul et al.
Kicking out oncogenic cells may promote the spread of tumours.
Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Key Regulator Unifying Neurodevelopment and Synaptic Function by Ramos et al.
One DISC to rule them all: DISC1 is a central regulator in a network of proteins involved in neurodevelopment and its disruption could segregate with risk of mental diseases.
Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis by Gumucio et al.
Why do lipids accumulate following muscle injury? A multi-omics study points to mitochondrial and lipid metabolism dysfunction.
A non-canonical arm of UPRER mediates longevity through ER remodeling and lipophagy by Daniele et al.
A neuronal stress response mediates longevity via cross-tissue signalling and upregulation of lipophagy.
Disrupting Transcriptional Feedback Yields an Escape-Resistant Antiviral by Chaturvedi et al.
Dr. Weinberger and colleagues create a new anti-viral drug modality that uses a 28 base pair piece of DNA to have the virus reduce its own progression without any sign of resistance.
Stable knockout and complementation of receptor expression using in vitro cell line derived reticulocytes for dissection of host malaria invasion requirements by Satchwell et al.
CRISPR meets red blood cells – a new model system to illuminate the roles of host proteins in malaria parasite invasion.
Unlimited genetic switches for cell-type specific manipulation by Garcia-Marques et al.
CaSSA: a new versatile system for intersectional gene expression enabling cell-type specific manipulations in vivo.