Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling by Stratman et al.
When not recycling cleans a mess; halting tumor-associated vascular overgrowth by blocking lipid recycling.
Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling by Wei et al.
Cell surface proteomics reveals new mTORC1-independent functions of TSC1 and suggests new avenues to develop therapies for TSC1-mutant tumours.
Precise tuning of gene expression output levels in mammalian cells by Michaels et al.
Michaels et al use sequence mismatches to engineer synthetic miRNA target sites with variable affinity, making a volume knob for adjusting transgene expression.
LADL: Light-activated dynamic looping for endogenous gene expression control by Rege et al.
Travelling over long distances: a new study uses blue light to make two (genomic) locations come together – providing an exciting new tool to study gene regulation.
Molecular recording of mammalian embryogenesis by Chan et al.
Molecular recording of mammalian development, one cell at a time.
Moving beyond P values: Everyday data analysis with estimation plots by Ho et al.
A visual, intuitive and widely accessible tool could finally help us move from asking “does it?” to “how much?”